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Table 5 Comparison of the most common (frequency > 2%) HLA-A/B, Cw/B and A/Cw two-loci haplotypes in Tunisians, Tunisian NPC patients and in ME

From: Associations between HLA Class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians

Haplotype TUNISIANS NPC TUNISIANS ME
  HF Dx100 D' χ2 p HF Dx100 D' χ2 p HF χ2 p
A/B              
A*020101 B*5001 0.045 2.20 0.20 8.9 < 0.01 0.044 2.70 0.33 16 < 0.001 0.029 3.50 NS
A*020101 B*440201 0.037 2.90 0.74 40.0 < 0.001 Not present      0.022 0.24 NS
A*2301 B*5001 0.030 2.00 0.29 14.0 < 0.001 (0.011)      Not present   
A*6802 B*1402 0.023 2.00 0.41 49.0 < 0.001 Not present      (0.015)   
A*020101 B*510101 0.020 1.10 0.25 5.1 < 0.05 (0.018)      (0.015)   
A*010101 B*570101 (0.003)      0.022 1.80 0.62 23 < 0.001 (0.015)   
A*020101 B*180101 (0.010)      0.030 1.80 0.33 10 < 0.01 0.022   NS
A*020101 B*440301 (0.013)      0.033 1.80 0.24 7.6 < 0.01 0.029   NS
A*2902 B*440301 (0.012)      0.021 1.60 0.29 15 < 0.001 Not present   
A*3402 B*0801 (0.006)      0.022 2.00 0.72 58 < 0.001 Not present   
Cw/B              
Cw*0701 B*0801 0.047 3.90 0.70 68.00 < 0.001 0.056 4.40 0.75 58 < 0.001 0.089 55.97 < 0.001
Cw*040101 B*4403 (0.016)      0.047 3.50 0.45 36 < 0.001 0.081 31.17 < 0.001
Cw*0602 B*5001 0.120 9.10 0.84 120.00 < 0.001 0.081 6.20 0.77 76 < 0.001 0.073 42.62 < 0.001
Cw*1701,03 B*4102 0.020 1.90 1.00 120.00 < 0.001 0.026 2.50 1.00 160 < 0.001 0.065 124.00 < 0.001
Cw*0701 B*4901 0.027 2.30 1.00 57.00 < 0.001 0.041 3.40 0.99 57 < 0.001 0.056 34.40 < 0.001
Cw*0802 B*1402 0.037 3.40 0.67 130.00 < 0.001 (0.007)      0.040 87.08 < 0.001
Cw*040101 B*3501 0.020 1.70 0.71 30.00 < 0.001 Not present      0.040 30.68 < 0.001
Cw*0501 B*4402 0.040 3.80 0.85 22.00 < 0.001 (0.018) 1.70 0.53 61 < 0.001 0.040 25.79 < 0.001
Cw*0501 B*1801 Not present      0.022 2.00 0.52 43 < 0.001 0.032 36.37 < 0.001
Cw*0602 B*4501 0.033 2.30 0.64 22.00 < 0.001 (0.011) 0.81 0.67 7.8 < 0.01 0.032 13.03 < 0.001
Cw*0702 B*070201 0.033 3.10 0.82 150.00 < 0.001 (0.018) 1.80 0.97 130 < 0.001 0.025 92.21 < 0.001
Cw*0202 B*440301 0.027 2.20 0.33 34.00 < 0.001 (0.012)      0.032   NS
Cw*1502 B*510101 0.033 3.20 1.00 180.00 < 0.001 0.044 4.10 1.00 140 < 0.001 (0.016)   
Cw*1601 B*440301 0.027 2.40 0.59 62.00 < 0.001 0.022 1.90 0.51 30 < 0.001 (0.008)   
Cw*1202 B*520101 0.023 2.30 1.00 30.00 < 0.001 0.030 2.90 0.89 220 < 0.001 Not present   
Cw*040101 B*5301 0.020 1.70 0.83 35.00 < 0.001 0.037 3.20 1.00 68 < 0.001 (0.008)   
Cw*120301 B*3801 0.020 1.90 1.00 140.00 < 0.001 (0.018)      Not present   
Cw*0602 B*1302 (0.017)      0.026 2.10 1.00 30 < 0.001 Not present   
Cw*020204 B*1503 (0.014)      0.033 3.20 1.00 280 < 0.001 (0.016)   
Cw*0701 B*180101 Not present      0.037 2.60 0.46 21 < 0.001 (0.008)   
Cw*0602 B*570101 (0.003)      0.033 2.70 1.00 40 < 0.001 (0.008)   
A/Cw              
A*020101 Cw*0602 0.061 2.40 0.18 7.60 < 0.01 0.023     NS 0.077 11.00 < 0.001
A*030101 Cw*0602 0.035 2.10 0.40 12.00 < 0.001 0.033 1.90 0.32 9.4 < 0.01 Not present   
A*010101 Cw*040101 0.033 2.20 0.29 17.00 < 0.001 (0.007)      Not present   
A*020101 Cw*0501,03 0.032 2.40 0.63 28.00 < 0.001 0.022 1.50 0.46 12 < 0.001 (0.012)   
A*2301 Cw*0602 0.032 1.60 0.27 6.50 < 0.05 (0.016)      Not present   
A*010101 Cw*0602 Not present      0.041 1.60 0.15 3.9 NS 0.026   NS
A*010101 Cw*0701 0.023     NS 0.037 1.60 0.14 4.2 NS (0.016)   
A*020101 Cw*040101 (0.014)      0.037 1.40 0.13 3.3 NS 0.040   NS
A*020101 Cw*0701 0.023     NS 0.036     NS 0.020   NS
A*2902 Cw*1601 (0.010)      0.022 1.90 0.52 48 < 0.001 Not present   
A*3402 Cw*0701 (0.007)      0.022 1.70 0.69 20 < 0.001 (0.016)   
  1. HF: haplotype frequency; SD: standard deviation; Dx100: linkage disequilibrium multiplied by 100; D': relative linkage disequilibrium; χ2: chi-square values In bold: alleles involved in NPC. In parenthesis: haplotypes present at low frequency (< 2%).
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Journal of Translational Medicine

ISSN: 1479-5876

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