Associations between HLA Class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians

Li, Xin; Ghandri, Nahla; Piancatelli, Daniela; Adams, Sharon; Chen, Deborah; Robbins, Fu-Meei; Wang, Ena; Monaco, Alessandro; Selleri, Silvia; Bouaouina, Noureddine; Stroncek, David; Adorno, Domenico; Chouchane, Lotfi; Marincola, Francesco M

doi:10.1186/1479-5876-5-22

Journal of Translational Medicine

Table 1 HLA-A, -B and -Cw allele frequencies in ME and TU

From: Associations between HLA Class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians

HLA-A allele (ME n = 73; TU n = 147)
	ME	TU		ME	TU		ME	TU
A*010101	0.137	0.088	A*110101	0.048	0.030	A*3301	0.055	0.031
A*0102	0	0.003	A*2301	0.082	0.078	A*3303	0	0.01
A*0103	0	0.007	A*240201	0.062	0.037	A33new	0	0.003
A*020101	0.178	0.173	A*250101	0.007	0.007	A*3402	0.021	0.01
A*0202	0	0.034	A*2601	0.007	0.031	A*3601	0	0.003
A*0205	0	0.024	A*2902	0.041	0.061	A*6601	0.021	0.02
A*0212	0	0.003	A*3001	0.014	0.031	A*680101	0.021	0.031
A*0285	0	0.003	A*3002	0.089	0.044	A*680102	0.021	0.014
A02new	0	0.003	A*3004	0.007	0.003	A*680201	0.048	0.054
A*030101	0.034	0.068	A*3010	0	0.003	A*7401	0.014	0.003
A*030103	0	0.003	A*310102	0.021	0.024	A*8001	0	0.007
A*0302	0.041	0.017	A*3201	0.034	0.034
HLA-B allele (ME n = 69; TU n = 148)
	ME	TU		ME	TU		ME	TU
B*070201	0.022	0.041	B*3508	0	0.014	B*4901	0.051	0.027
B*0705,06	0.007	0.003	B*3701	0.007	0.007	B*5001	0.073	0.139
B0801*	0.087	0.064	B*3801	0.014	0.020	B*5002	0.043	0.014
B*1302°°	0	0.017	B*390602	0	0.003	B*510101,02	0.043	0.054
B*1401	0.014	0.010	B*3910	0.007	0.007	B*5108	0	0.003
B*1402	0.036	0.054	B*3920	0	0.003	B*520101,02	0.007	0.024
B*1403	0	0.010	B*4001	0	0.010	B*5301^^	0.014	0.024
B*150101	0	0.014	B*4002	0.007	0.003	B*5303	0	0.003
B*1503	0.014	0.017	B*4101	0	0.017	B53new	0	0.003
B*1510	0	0.004	B*4102	0.065	0.020	B*5501	0	0.003
B*1516	0	0.017	B*4201	0	0.017	B*570101	0.014	0.003
B*151701	0	0.007	B*4202	0.007	0.007	B*5702	0	0.003
B*180101	0.051	0.023	B*4402	0.094	0.047	B*570302	0.007	0
B*2702	0.007	0.007	B*440301	0.116	0.071	B*5801	0.014	0.027
B*2703	0.007	0	B*440302	0.007	0	B*5802	0.007	0.003
B*2705,13^	0.021	0.010	B*4405	0	0.003	B*7301	0	0.007
B*350101,42	0.043	0.027	B*4427	0	0.007	B*7801	0.014	0
B*3502	0.007	0.017	B*4501	0.043	0.047
B*3503	0.014	0.014	B*470101	0.007	0.003
HLA-Cw allele (ME n = 63; TU n = 147)
	ME	TU		ME	TU		ME	TU
Cw*0102	0	0.007	Cw*0602	0.183	0.218	Cw*140201	0.008	0.027
Cw020202**	0.095	0.054	Cw*0701,06°	0.183	0.129	Cw*150201	0.016	0.034
Cw*0210	0.016	0.017	Cw*070201	0.032	0.054	Cw*150501,02	0.016	0.014
Cw*0302	0	0.010	Cw*0704,0711	0.016	0.010	Cw*1601	0.032	0.044
Cw*030301	0	0.003	Cw*0802	0.056	0.058	Cw*1602	0.016	0.007
Cw*030401, 02°°°	0	0.014	Cw*120201,02	0.008	0.024	Cw*160401	0	0.003
Cw*040101	0.159	0.126	Cw*120301	0.008	0.044	Cw*1701,02,03^^^	0.071	0.051
Cw*0501,03	0.087	0.048	Cw12new	0	0.003

Alleles having a frequency > 5% are in bold. °Including Cw*070101,02; **Two samples in this group were assigned as B*080101; °°One sample in this group was assigned as B*130201; ^Two samples in this group were assigned as B*270502 (1ME, 1TU); ^^Two samples in this group were assigned as B*530101; ***One sample in this group was assigned as Cw*0202; °°°One sample in this group was assigned as Cw*0304; ^^^Cw*1703, af = 0.063 in ME.
Not discriminated alleles due to polymorphisms outside the assayed exons are listed separated by ",". Nomenclature was updated until the sixth digit; seventh and eighth digits were not included in the table. In case of ambiguous allele combinations, the most frequent allele combination was included in the analysis.
No statistically significant differences were identified in any comparison between the Tunisian and Moroccan cases.

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ISSN: 1479-5876

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