From: Disaggregation and invasion of ovarian carcinoma ascites spheroids
Patient # | 2 | 3 | 4 | 5 | 6 | 8 | 9 | 10 |
---|---|---|---|---|---|---|---|---|
Diagnosis | Poorly differentiated papillary serous adenocarcinoma | Papillary serous adenocarcinoma | Primary peritoneal carcinoma with invasive implants | Poorly differentiated serous papillary carcinoma | Serous papillary carcinoma | Serous papillary carcinoma | Metastatic serous adenocarcinoma | Poorly differentiated adenocarcinoma |
Stage | IIIC | IIIC | IIIC | IIIC | IIIC | IIIC | IIIC | IV |
Grade | 3 | 2 | 2 | 3 | 3 | 2 | 3 | 3 |
Initial CA125 | 860 | 168 | 1950 | 2800 | 366 | 640 | 191 | 6640 |
Debulking | optimal | optimal | optimal | suboptimal | Â | optimal | optimal | optimal |
Treatment | 6 cycles Carbo/Taxol | 6 cycles Carbo/Taxol | CDDP/Taxol | Failed several chemos: Taxol, Carbo, Gemzar | Taxol/Carbo 1 cycle | 4 drugs/8 cycles | 6 cycles (x2) Carbo/Taxol, | 6 cycles Carbo/Taxol |
Surgery to Recurrence (Months) | 22 | 36 | 8 | Progressive disease | Progressive disease | 11 | 18 | 14 |
Overall Survival (Months) | 39 | Alive with disease | 16 | 17 | 1 | Alive with disease | Alive | 34 |
Age at diagnosis | 58 | 45 | 63 | 70 | 75 | 29 | 70 | 52 |
Family History | Aunt-breast cancer | Mother-ovarian, breast cancer; maternal grandmother-breast cancer; aunt-breast cancer | Â | Â | Â | Mother-ovarian cancer; paternal aunt (x2)-breast cancer; maternal great aunt-gynecological cancer | Sister-breast cancer | Grandmother-uterine cancer; aunt-breast cancer; great aunt (x4)-gynecological cancer; grandmother-ovarian cancer |