Figure 5

CTL recognition of CaSki and MS751(HPV-18+) cell lines treated with H and VA. T lymphocytes derived from patients with squamous cervical cancer, positives either for HPV-16 or -18 infection (Table 2) were stimulated with the peptides TLGIVCPIC and YMLDLQPETT of the E7 HPV-16 protein and the peptide KLPDLCTEL of the E6 HPV-18 protein respectively and their cytolytic activity was tested by a standard 4-h 51Cr release assay against CaSki(HPV-16+) or MS751(HPV-18+) without treatment (WT) or previously treated with H, VA or H plus VA as indicated.