Figure 4
From: A novel assay for analysis of the regulation of the function of human osteoclasts
Application of assay to assessment of potency of cathepsin K inhibitors. Results expressed as CTX-I after incubation in inhibitor for 24 h, as percentage of CTX-I in the same culture measured in the 24 h before addition of the inhibitor ('basal' CTX-I release). Mean values (nM) of basal CTX-I groups were (range): A: 112–333; B: 199–379; C: 77–137; D: 185–322. n = 4 cultures per group. * p < 0.05 vs no inhibitor.