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Table 4 In vitro immunomonitoring (Miltenyi Test): comparison between IFN-γ secreting lymphocytes after stimulation with KLH and ATL/ATH, and DTH test and clinical outcome

From: Improved overall survival in dendritic cell vaccination-induced immunoreactive subgroup of advanced melanoma patients

Patient ID Stimulation Baseline After 4/6 Vaccinations After 8/13 Vaccinations DTH Clinical Response
4 S.P.a KLH 0 0   Negative PD
  L 0 0   Negative  
9 P.M.b KLH   0   Negative PR
  L   0   Negative  
10
P.M.b
MR
  KLH 0 0 186 Positive
  L 0 0 0 Positive  
12
G.D.b
  KLH
CR
133 1238 2253 Positive
  L 56 456 13405 Positive  
14 T.A.b KLH 4 356 73 Positive MR
  H 0 0 0 Negative  
16 C.P.b KLH 0 103   Positive PD
  H 0 0   Negative  
18 L.B.b KLH 264 110   Negative PD
  L 0 0   Negative  
19
M.J.L.b
SD
  KLH 0 0   Positive
  L 0 0   Positive  
20
O.M.b
PD
  KLH 0 0   Negative
  L 0 0   Negative  
21
M.R.b
SD
  KLH 0 99   Positive
  L 0 292   Positive  
  1. DTH, delayed-type hypersensitivity; L, autologous tumor lysate; H, autologous tumor homogenate; KLH, keyhole limpet hemocyanin.
  2. a = pts treated with iDC.
  3. b = pts treated with mDC.
  4. bold = data corresponding to test