Figure 9

Genes differentially expressed by CD4 and CD8 cells upon in vitro exposure to rIL-2 (300 IU/ml) depending upon the presence or absence of the rest of the PBMC population (for labeling see Figure 6): a) genes differentially modulated between CD4 and CD8 cells that were stimulated in the whole PBMC population and subsequently separated (paired Student t test p₂-value < 0.05);b) genes differentially modulated between CD4 and CD8 cells that were stimulated after being separated from the whole PBMC population by negative selection (paired Student t test p₂-value <0.05); c) selected genes differentially modulated between CD4 and CD8 cells that were stimulated in the whole PBMC population and subsequently separated (from series in panel a) associated with T cell activation/effector function; c) selected genes differentially modulated between CD4 and CD8 cells that were stimulated after separation from the whole PBMC population by negative selection (from series in panel b) associated with T cell activation/effector function.