Figure 1

B16F10 melanoma tumor growth in hgp100_25–33 vaccinated and cytokine treated lymphopenic mice. Tumor size is presented as the mean (mm²) ± SEM of the cumulative analysis of replicate mice (≥ 15) for each test group from 3 separate experiments. Cytokines were administered for 5 consecutive days beginning on day 14 when the average tumor size for vaccinated mice from all test groups in 3 experiments was 26 mm² ± 2.4 mm (N = 73 mice). By day 30 IL-21 + low-dose IL-2 treated mice showed significant inhibition of tumor growth compared to the vaccine control (p < 0.0001), or compared to vaccinated mice treated with IL-2 (p = 0.0002) or IL-21 only (p = 0.0024).