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Table 1 Agents targeting DNA methylation and histone deacetylase in preclinical and clinical development

From: Hydralazine target: From blood vessels to the epigenome

DNA methylation inhibitors
deoxycytidine analogs:
5-azacytidine, 5-aza-2-deoxycytidine, 1-β-D-arabinofuranosil 5-azacytosine, dihydro- 5-azacytidine
nucleic acid-based:
MG98 antisense oligonucleotide
cytidine deaminase analogs:
zebularine
non-nucleoside analogs:
(-)-epigallocatechin-3-gallate, procaine, procainamide, hydralazine, RG108, psammaplins
Histone deacetylase inhibitors
Small molecular weight carboxilates:
sodium butyrate, valproic acid, sodium phenylbutyrate and pivaloyloxymethyl butyrate
Hydroxamic acids:
SAHA, trichostatin A, SBHA
Benzamides:
CI-994, MS-275
Epoxyketones:
trapoxin B, 2-amino-8-oxo-9,10-epoxydecanoic acid
Cyclic peptides:
apicidin, depsipeptide
Hybrid molecules:
CHAP 31, CHAP50
Miscellaneous:
Cyclostellettamines, Carbamazepine
  1. Adapted from reference 106.