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Table 4 Chemokines involved in ovarian pathogenesis

From: Ovarian cancer, the coagulation pathway, and inflammation

Chemokine Receptor Cells targeted Comments
CCL22 CCR4 CD25+CD4+ regulatory T cells Forster tumor immune escape
CCL2 CCR2 Activated T cells, monocytes, and DC Deregulate CD8+ T cells and CD68+ macrophage
CCL3 CCR2 Activated T, NK, MO, Eosinophils Inflammatory cells migration
CCL4 CCR5 DC, MO, NK Inflammatory cells migration
CCL5 CCR2 Activated T, NK, MO, Eosinophils Inflammatory cells migration
CCL7 CCR2 Activated T, NK, MO, Eosinophils Inflammatory cells migration
CCL18 Unknown MOs/MAs MA produced but not induced in EOC
CXCL8 CXCR1, CXCR2 Neutrophils and resting T cells Angiogenesis, metastasis
CXCL12 CXCR4 Neutrophils, resting T cells, activated T and B cells, and macrophages CXCR4 is preferentially expressed on EOC cells