Table 4 Chemokines involved in ovarian pathogenesis
From: Ovarian cancer, the coagulation pathway, and inflammation
Chemokine | Receptor | Cells targeted | Comments |
|---|---|---|---|
CCL22 | CCR4 | CD25+CD4+ regulatory T cells | Forster tumor immune escape |
CCL2 | CCR2 | Activated T cells, monocytes, and DC | Deregulate CD8+ T cells and CD68+ macrophage |
CCL3 | CCR2 | Activated T, NK, MO, Eosinophils | Inflammatory cells migration |
CCL4 | CCR5 | DC, MO, NK | Inflammatory cells migration |
CCL5 | CCR2 | Activated T, NK, MO, Eosinophils | Inflammatory cells migration |
CCL7 | CCR2 | Activated T, NK, MO, Eosinophils | Inflammatory cells migration |
CCL18 | Unknown | MOs/MAs | MA produced but not induced in EOC |
CXCL8 | CXCR1, CXCR2 | Neutrophils and resting T cells | Angiogenesis, metastasis |
CXCL12 | CXCR4 | Neutrophils, resting T cells, activated T and B cells, and macrophages | CXCR4 is preferentially expressed on EOC cells |