Ambiguous allele combinations in HLA Class I and Class II sequence-based typing: when precise nucleotide sequencing leads to imprecise allele identification

Table 2 Nature and Resolution of HLA-A and -B Allele Ambiguities

	HLA-A Locus	HLA-B Locus
Portion of alleles with ambiguities	41%	24%
Most frequently involved alleles	A*01, 02, and 24	B*7, 8, 15, 35, and 44
Methods used to resolve ambiguities	Exon 4 sequencing (51%)	Many different methods
	A*02 subtyping (30%)

ISSN: 1479-5876