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Table 1 Profiles of patients enrolled in this study and clinical responses to the vaccination

From: Phase I clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer

patient no.

age

sex

dose of peptide (mg)

adverse events

tumor marker

evaluation of CT imagea)

DTH skin test

1

63

M

0.1

anemia

decreased

MR

--

2

53

M

0.1

--

not decreased

PD

--

3

42

M

0.1

--

decreased

NC

--

4

54

F

0.1

--

   

5

65

M

0.1

--

decreased

PD

--

6

64

F

0.1

general malaise

decreased

PD

+

7

48

F

1.0

--

decreased

PD

--

8

62

F

1.0

--

not decreased

PD

--

9

64

M

1.0

--

decreased

PD

--

10

52

M

1.0

--

not decreased

PD

+

11

58

M

1.0

--

not decreased

NC

+

12

58

F

10.0

fever

not decreased

PD

--

13

62

F

10.0

--

not decreased

PD

+

14

72

M

10.0

--

not decreased

PD

+

15

71

M

10.0

--

   

16

67

M

10.0

--

not decreased

PD

--

17

59

F

10.0

--

not decreased

NC

+

  1. a) MR: minor response, NC: no change, PD: progressive disease