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Table 6 Soluble factor (pg/ml) concentrations in the serum of 10 patients who completed the study (only factors that demonstrated significant changes in concentration between the 1st and 4th dose are shown)

From: Forecasting the cytokine storm following systemic interleukin (IL)-2 administration

Soluble Factor

Average before IL-2

STD error before Il-2

Average after 1 dose

STD error after 1 dose

Average after 4 doses

STD error after 4 doses

pvalue after 1 vs after 4 doses

Bonferroni correction

I309

18

4

52

8

222

25

0.00004

0.00232

MIP3b

18

4

347

51

33836

5140

0.00007

0.00414

TARC

248

59

478

112

8993

1517

0.00015

0.00882

E-Selectin

106029

5703

118981

5972

377934

40503

0.00018

0.01034

Exodus2

419

71

307

26

1108

157

0.00028

0.01628

MDC

586

111

644

109

1272

214

0.00029

0.01740

ITAC

29

4

110

26

438

57

0.00033

0.01935

Lymph

111

22

259

39

639

95

0.00083

0.04905

MCP3

10

1

17

2

53

8

0.00101

0.05956

TIMP1

198383

20136

242215

25530

1021646

178036

0.00116

0.06856

HGF

8281

2359

10836

1791

17298

1311

0.00148

0.08712

IL15

0

0

6

2

14

2

0.00148

0.08719

MMP13

839

221

1081

251

1742

171

0.00163

0.09604

MCP2

32

9

1500

291

296

34

0.00174

0.10287

MIP1b

512

205

30149

6560

4072

794

0.00180

0.10631

TNFR2

3195

259

6014

628

16353

3113

0.00221

0.13028

TNFa

521

65

610

59

839

74

0.00281

0.16587

MCP1

984

227

81270

13486

31267

4583

0.00447

0.26392

NAP2

9479881

2329514

10970212

2240959

8251596

2122243

0.00482

0.28444

IL5

0

0

8

2

40

10

0.00564

0.33291

MMP8

1187

455

3340

500

5081

927

0.00852

0.50244

MMP2

210099

37913

201099

41748

399516

50101

0.00889

0.52449

MCP4

84

19

264

71

1663

495

0.00932

0.54966

IL6R

23556

1882

26254

3045

19437

1316

0.01011

0.59636

ICAM1

499363

62669

501688

90740

2313052

682964

0.01143

0.67431

MMP3

27613

6960

24603

5418

59390

16227

0.01149

0.67778

MMP10

1467

220

1694

218

3247

528

0.01209

0.71314

TIMP2

75277

5629

85674

4973

108359

4266

0.01334

0.78706

VCAM1

310701

30008

335385

17713

1278753

336280

0.01469

0.86698

IP10

146

18

1571

273

2940

390

0.01571

0.92712

IL10

3

1

45

23

179

54

0.02652

1.56497

IL18

67

11

93

19

167

43

0.03116

1.83873

TNFR1

1641

112

4702

512

6067

651

0.03126

1.84407

IL16

13

6

19

11

104

43

0.04434

2.61591

Rantes

40861

10853

56208

8799

34797

6495

0.04881

2.87988

  1. Soluble Factors levels were averaged across 10 patients after 1 and 4 doses of IL-2. A paired 2-tailed student t test was used to assess significance with an arbitrary cutoff of p= 0.05. Bonferroni's correction was applied to the data set by correcting for a total of 59 soluble factors.
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Journal of Translational Medicine

ISSN: 1479-5876

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