Figure 5
From: Forecasting the cytokine storm following systemic interleukin (IL)-2 administration
Soluble Adhesion molecules in serum as markers of systemic and vascular inflammation: correlation with high dose IL-2 immunotherapy and other therapies. The presence of increased expression of soluble adhesion molecules (sICAM, sVCAM, sV-Selectin) detected in our study, have also been reported in the serum of patients undergoing TNF alpha and IL-12 immunotherapy. Furthermore, increased level of the inflammatory cytokines (IL-8, IL-6) and soluble TNF receptor (sTNFRI) confirmed previous findings in patients receiving high dose immunotherapy with IL-2.