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UV exposure and melanoma prognostic factors : results from Clinical National Melanoma Registry (CNMR)

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Background

Previous studies have reported an association between sun exposure and improved cutaneous melanoma (CM) survival. We analysed the association of UV exposure with prognostic factors and outcome in the National Clinical Melanoma Registry.

Methods

Clinical and socio-demographic features were collected melanoma patients at diagnosis, together with information on sunbed exposure and sunny holidays. Analyses were carried out to investigate the associations between UV exposure and melanoma prognostic factors.

Results

From December 2010, we retrieved information from 3299 melanoma patients from 39 IMI (Intergruppo Melanoma Italiano) sites geographically representative. 40% of the patients are over 60 years old, 52% are men, 49% live in the north of Italy and 56% are at high educational level (at least high school). 8% of the patients have melanoma familiarity and 55% have fair phenotype (Fitzpatrick skintype I or II). 2% have metastases and 11% lymph-node involvement. 8% have very thick melanoma (Breslow>4 mm) and 21% ulcerated melanoma.

Holidays in the sun five years before CM diagnosis, among non-metastatic patients, were significantly associated with lower Breslow thickness (p=0.003), after multiple adjustment including socio-demographic status, degree of doctor making the diagnosis and residence. Sunbed exposure is not significantly associated with Breslow thickness.

Conclusions

Holidays in the sun were associated with thinner melanomas. However, these results do not prove a direct causal effect of sun exposure on survival since other confounding factors, such as Vitamin D serum levels, may play a role.

References

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    Yang L, Lof M, Veierod MB, Sandin S, Adami HO: Ultraviolet exposure and mortality among women in sweden. Cancer Epidemiol Biomarkers Prev. 2011, 20: 683-690. 10.1158/1055-9965.EPI-10-0982.

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    Gandini Sara, De Vries Esther, Tosti Giulio, Botteri Edoardo, Spadola Giuseppe: Sunny holidays before and after melanoma diagnosis are respectively associated with lower Breslow thickness and lower relapse rates in Italy. Plos One.

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Author information

Correspondence to Maurizio Montella.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Keywords

  • Melanoma
  • Causal Effect
  • Melanoma Patient
  • Cutaneous Melanoma
  • High Educational Level