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Table 3 Gene expression analysis of cancer pathways

From: In vitro biosafety profile evaluation of multipotent mesenchymal stem cells derived from the bone marrow of sarcoma patients

   

MSC-SAR vs MSC-CTRL P03

MSC-SAR vs MSC-CTRL P10

U2OS vs MSC-CTRL P03

GENE SYMBOL

Refseq

Description

Fold Regulation

T-TEST p value

Fold Regulation

T-TEST p value

Fold Regulation

T-TEST p value

ANGPT2

NM_001147

Angiopoietin 2

3,60

0,017031

3,54

0,001587

2,01

0,123058

BRCA1

NM_007294

Breast cancer 1, early onset

1,56

0,184634

2,59

0,005080

13,19

0,000088

CDC25A

NM_001789

Cell division cycle 25 homolog A (S. pombe)

2,01

0,030181

2,44

0,011524

15,56

0,000083

CFLAR

NM_003879

CASP8 and FADD-like apoptosis regulator

-3,43

0,013343

-1,91

0,017928

-1,42

0,115505

CHEK2

NM_007194

CHK2 checkpoint homolog (S. pombe)

1,03

0,930306

1,23

0,735103

7,49

0,000340

COL18A1

NM_030582

Collagen, type XVIII, alpha 1

-2,85

0,034861

-1,14

0,967097

2,94

0,018415

E2F1

NM_005225

E2F transcription factor 1

1,69

0,152813

2,64

0,036988

18,50

0,000019

GZMA

NM_006144

Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

4,14

0,064832

3,86

0,021397

2,28

0,018937

IFNA1

NM_024013

Interferon, alpha 1

2,15

0,231676

4,32

0,000719

-4,17

0,208829

IGF1

NM_000618

Insulin-like growth factor 1 (somatomedin C)

3,98

0,023798

5,26

0,003415

1,41

0,704213

MMP9

NM_004994

Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)

4,05

0,033049

2,76

0,957572

152,53

0,000000

PDGFB

NM_002608

Platelet-derived growth factor beta polypeptide

2,41

0,057864

2,80

0,027891

174,40

0,000107

SERPINB5

NM_002639

Serpin peptidase inhibitor, clade B (ovalbumin), member 5

4,32

0,056954

3,54

0,010117

4,04

0,000712

TNF

NM_000594

Tumor necrosis factor

4,04

0,030749

2,77

0,010705

1,54

0,285973

VEGFA

NM_003376

Vascular endothelial growth factor A

-1,97

0,006089

-6,84

0,008108

-12,44

0,000009

  1. Genes differentially expressed in MSC-SAR compared to MSC-CTRL at early and late passages characterized in the Human Cancer Pathway Finder PCR Array (RT2 Profiler PCR Array PAHS-033R, SABioscience), and analyzed using the provided RT2 Profiler PCR Array Data Analysis v. 3.5 software [32]. Results of the same genes analyzed in U2OS cells are reported for comparison. Bold characters indicate genes up- or down-regulated by ≥ 2-fold and with a p-value ≤ 0.05. The analysis was performed on four MSC-CTRL, four MSC-SAR samples and three independent samples of sub-confluent U2OS cells.
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Journal of Translational Medicine

ISSN: 1479-5876

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