Up-regulation of heme oxygenase-1 after infarct initiation reduces mortality, infarct size and left ventricular remodeling: experimental evidence and proof of concept

Table 3 Values of coronary resistance in isolated heart in Langendorff configuration

	Sham group	MI group	CoPP-MI group
Perfusion at constant pressure (70 mmHg)
Baseline	8.8 ± 0.5	13.4 ± 0.5^**	9.2 ± 0.5^#
65 min	12.5 ± 1.3	32.7 ± 3.3^**	17.8 ± 1.8^#
Perfusion at low pressure (30 mmHg) and reperfusion
Baseline	9.3 ± 0.6	13.6 ± 0.7^**	8.8 ± 0.6^#
At 20 min low pressure	15.0 ± 1.6	26.1 ± 2.0^*	13.2 ± 1.5^#
Reperfusion	8.5 ± 0.5	19.3 ± 0.9^**	11.5 ± 0.8

Values are mean ± SEM. *p < 0.01 and **p < 0.001 vs sham-operated; #p < 0.01 vs MI group.

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