Figure 2

Serum anti-AdV neutralizing antibodies. The MFI of AdVeGFP-transduced A549 cells incubated with dilutions of serum is shown, with positive and negative assay controls. A: Results from patient 7 show no evidence of anti-AdV neutralizing antibody induction. Baseline levels show no inhibition of AdVeGFP transduction of A549 cells. B: Results from patient 8 show that the AdV boost induced increased titers of anti-AdV neutralizing antibodies. Patient 8 shows positive baseline neutralizing antibodies as well.