Table 3 Cytokine expression in tissue of patients with metallosis versus aseptic loosening

CXCL8

1927.3 ± 328.4+

106.2 ± 106.6

580 ± 316.2

379.2 ± 494.1

27 ± 20.8+

181.3 ± 305.4

IL-1

179.5 ± 293.5+

11.2 ± 12.1

65 ± 44.7

47.9 ± 48.4

9 ± 3.5+

12.2 ± 18.8

RANK

5.6 ± 5.9

9.5 ± 8.8

11 ± 4.5

26.3 ± 32.7

8.2 ± 5.7

19.3 ± 22.9

RANKL

4.4 ± 7

17.3 ± 18.7

11 ± 8.2

44.7 ± 50.2

0.2 ± 0.4

2 ± 4.9

Cathepsin K

2708.8 ± 2139.7

4794.9 ± 2817.2

3313.3 ± 1646.1

6871.6 ± 4937.7

968.4 ± 392.4

2958.5 ± 3390.7

CCL2

2005.7 ± 1321.5

990.7 ± 512.6

3439.8 ± 2892.6

1196.3 ± 575.3

652 ± 144.8

1065.8 ± 1030.5

CD14

1075.5 ± 659.1+

563.2 ± 321+

823.8 ± 488.9

687.8 ± 417.2

288.8 ± 151.3 +

305.2 ± 175 +

CD3

64.1 ± 59.8

29.5 ± 15.7

111.5 ± 77.1

62.2 ± 69.9

42.2 ± 26.5

45.7 ± 19.3

TNFα

10.6 ± 10

3.7 ± 2.2

12.8 ± 7

5.7 ± 3.7

5.8 ± 3.3

4.2 ± 6.2

CXCL10

241.4 ± 246.2*

25.9 ± 17.6

183.8 ± 130*

41.7 ± 26.9 *

131.6 ± 147.8

607.2 ± 1167.8

MRP14

4899 ± 2656.3 *

806 ± 65

48214.3 ± 91617.3*

2461.3 ± 2529.1

377.4 ± 396

2186.7 ± 2080.3

CXCL2

241.2 ± 126.5 *

73.2 ± 59.2

670 ± 635.2

133.8 ± 100.2

92.8 ± 51.6

262.3 ± 467.9