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Table 3 Univariate analysis of clinicopathological and immunohistochemical parameters

From: The clinical significance of tumor-infiltrating neutrophils and neutrophil-to-CD8+ lymphocyte ratio in patients with resectable esophageal squamous cell carcinoma

Univariate analysis Disease-free survival Overall survival
HR (95% CI) P value HR (95% CI) P value
Gender 1.182 (0.64-2.185) 0.593 1.154 (0.608-2.19) 0.661
Age 1.092 (0.665-1.793) 0.727 1.27 (0.753-2.144) 0.37
Tumor location     
Upper Ref. 0.213 Ref. 0.6
Middle 0.517 (0.2554-1.202) 0.083 0.653 (0.286-1.493) 0.312
Lower 0.553 (0.545-1.608) 0.135 0.698 (0.296-1.65) 0.413
Tumor length 1.172 (0.715-1.923) 0.529 1.343 (0.797-2.262) 0.269
Differential Grade     
Well Ref. 0.095 Ref. 0.17
Moderate 1.947 (1.045-3.629) 0.036 1.881 (0.971-3.645) 0.061
Poor 1.334 (0.666-2.672) 0.417 1.449 (0.697-3.015) 0.321
T stage     
T1 Ref. 0.121 Ref. 0.026
T2 1.359 (0.539-3.454) 0.519 1.425 (0.477-4.253) 0.526
T3 1.954 (0.871-4.385) 0.104 2.706 (1.061-6.9) 0.037
T4 3.328 (1.113-9.951) 0.031 4.618 (1.404-15.196) 0.012
LN metastasis 2.506 (1.51-4.157) <0.001 2.469 (1.455-4.188) 0.001
Positive LN number     
0 Ref. 0.001 Ref. 0.002
1 3.479 (1.756-6.89) <0.001 3.01891.491-6.112 0.002
≥2 2.117 (1.176-3.812) 0.012 2.20391.195-4.063 0.011
pTNM stage     
I Ref. <0.001 Ref. <0.001
II 2.03 (0.919-4.482) 0.08 2.334 (0.951-5.729) 0.064
III 4.365 (1.962-9.713) <0.001 5.254 (2.139-12.91) <0.001
Treatment regimens     
Surgery alone Ref. 0.081 Ref. 0.063
Adjuvant chemotherapy 0.839 (0.354-1.993) 0.692 0.747 (0.291-1.919) 0.545
Adjuvant radiation 1.821 (0.961-3.451) 0.066 1.99 (1.04-3.807) 0.038
Adjuvant chemoradiation 2.152 (0.992-4.67) 0.053 2.054 (0.902-4.676) 0.086
Immunohistochemical markers     
Intratumoral neutrophils 2.505 (1.496-4.196) <0.001 2.559 (1.487-4.406) <0.001
Intratumoral CD8+ lymphocytes 0.896 (0.546-1.471) 0.665 0.959 (0.57-1.613) 0.875
Intratumoral NLR 1.279 (0.78-2.097) 0.329 1.316 (0.783-2.214) 0.3
Peritumoral neutrophils 1.035 (0.63-1.7) 0.893 1.119 (0.664-1.886) 0.672
Peritumoral CD8+ lymphocytes 0.952 (0.581-1.561) 0.846 1.032 (0.613-1.735) 0.907
Peritumoral NLR 1.306 (0.788-2.165) 0.3 1.292 (0.761-2.195) 0.343
  1. LN lymph node, pTNM pathological tumor node metastasis, NLR CD66+ neutrophil-to-CD8+ lymphocyte ratio, HR hazard ratio, CI confidence interval, Ref. reference, Values in bold signify p < 0.05.