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Table 4 Multivariate analysis of biomarkers for overall survival using Cox regression model

From: A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

  Variable Hazard ratio 95% CI P value
Step 1 CEA: < 100 (ng/ml) versus ≥100 0.209 0.017 to 2.542 0.220
Local skin reaction: grade2 versus grade1 0.171 0.013 to 2.190 0.175
CTL response: 2 or more versus 1 or less (within 3 courses) 0.078 0.011 to 0.548 0.010
Step 2 Local skin reaction: garde2 versus garde1 0.048 0.007 to 0.326 0.002
CTL response: 2 or more versus 1 or less (within 3 courses) 0.101 0.016 to 0624 0.014
  1. CI, confidence interval.