A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

Table 4 Multivariate analysis of biomarkers for overall survival using Cox regression model

	Variable	Hazard ratio	95% CI	P value
Step 1	CEA: < 100 (ng/ml) versus ≥100	0.209	0.017 to 2.542	0.220
	Local skin reaction: grade2 versus grade1	0.171	0.013 to 2.190	0.175
	CTL response: 2 or more versus 1 or less (within 3 courses)	0.078	0.011 to 0.548	0.010
Step 2	Local skin reaction: garde2 versus garde1	0.048	0.007 to 0.326	0.002
Step 2	CTL response: 2 or more versus 1 or less (within 3 courses)	0.101	0.016 to 0624	0.014

ISSN: 1479-5876