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Table 2 Dominant proteins associated with T cell activities

From: Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer

Ref. Activity Protein Expression Functions
10 T cell differentiation Macrophage migration inhibitory factor (MIF) Up-regulated Cell resque, defense, death, ageing
   Programmed cell death 4 (pdcd4) Up-regulated Cell resque, defense, death, ageing
   p21-activated kinase 2 (Pak2) Down-regulated Signal transduction
   Cdc42 Down-regulated Signal transduction
   Mortalin 2 (Mot-2) Down-regulated Protein destination
13 T cell proliferation Peroxiredoxin 1 Up-regulated A scavenger of reactive organic hydroperoxides
   Proteasomes Up-regulated A large multisubunit proteolytic complex that involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
   Triosephosphate isomerase (TIM) Up-regulted Enzyme of metabolic pathways like converting glyceraldehyde-3-phosphate to dehydroxyacetone phosphate in the glycolytic pathway
   Galectin-1, Chain A Down-regulated An anti-inflammatory agent which triggers homeostatic signals to shut off T cell effector functions such as cell proliferation, cell death and cytokines synthesis, cell adhesion and inflammation
23 T cell supression Haptoglobin Up-regulated Anti-inflammatory activities
   Nonintegrin 67 kDa laminin receptor (LR) Down-regulated Lymphocyte migration
   MRP8 Up-regulated Marker proteins for activated or recruited phagocytes
27 T cell activation Calreticulin (CRT) Identified Damage-associated molecular pattern molecules, inducing immunogenic apoptosis
   Endoplasmic reticulum protein (ERp57)
   Vimentin