Table 2 Dominant proteins associated with T cell activities
From: Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer
Ref. | Activity | Protein | Expression | Functions |
|---|---|---|---|---|
10 | T cell differentiation | Macrophage migration inhibitory factor (MIF) | Up-regulated | Cell resque, defense, death, ageing |
| Â | Â | Programmed cell death 4 (pdcd4) | Up-regulated | Cell resque, defense, death, ageing |
| Â | Â | p21-activated kinase 2 (Pak2) | Down-regulated | Signal transduction |
| Â | Â | Cdc42 | Down-regulated | Signal transduction |
| Â | Â | Mortalin 2 (Mot-2) | Down-regulated | Protein destination |
13 | T cell proliferation | Peroxiredoxin 1 | Up-regulated | A scavenger of reactive organic hydroperoxides |
| Â | Â | Proteasomes | Up-regulated | A large multisubunit proteolytic complex that involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway |
| Â | Â | Triosephosphate isomerase (TIM) | Up-regulted | Enzyme of metabolic pathways like converting glyceraldehyde-3-phosphate to dehydroxyacetone phosphate in the glycolytic pathway |
| Â | Â | Galectin-1, Chain A | Down-regulated | An anti-inflammatory agent which triggers homeostatic signals to shut off T cell effector functions such as cell proliferation, cell death and cytokines synthesis, cell adhesion and inflammation |
23 | T cell supression | Haptoglobin | Up-regulated | Anti-inflammatory activities |
| Â | Â | Nonintegrin 67Â kDa laminin receptor (LR) | Down-regulated | Lymphocyte migration |
| Â | Â | MRP8 | Up-regulated | Marker proteins for activated or recruited phagocytes |
27 | T cell activation | Calreticulin (CRT) | Identified | Damage-associated molecular pattern molecules, inducing immunogenic apoptosis |
| Â | Â | Endoplasmic reticulum protein (ERp57) | ||
| Â | Â | Vimentin |