Figure 5From: Potential therapeutic targets for hypoxia-induced pulmonary artery hypertension 5-HD down-regulates hypoxic-induced pulmonary artery hypertension. 5-HD could inhibit mitoKATP channels and block the hypoxic depolarization of mitochondrial membrane potential of PASMCs via Kv1.5 channels, inhibiting the circulating inflammatory cytokines MCP-1 and down-regulating TGF-β1 signaling way, or inhibiting PAH by oxygen free radicals (ROS)-related signal pathways.Back to article page