Figure 1
From: Potential therapeutic targets for hypoxia-induced pulmonary artery hypertension
Effects of mitochondrial ATP-sensitive potassium channel inhibitor (5-HD) on the development of pulmonary hypertension. (A) Pulmonary arterial pressure (PAP) according to a right cardiac catheterization procedure; (B) The mean values of PAP (mPAP); (C) The Optimal density (OD) of a-actin; (D) Immuno-histochemical staining of smooth muscle a-actin expression (×200); (E) Ultrastructural morphology in rat lung tissues (×6000). Rats were treated with vehicle and normoxia as Controls, with vehicle and hypoxia (Hypoxia + V), or with 5-HD and hypoxia (Hypoxia + 5-HD). Each group includes 8 animals and values were expressed as mean ± SD. *and + stand for p values less than 0.05, as compared with Controls and Hypoxia + V group, respectively.