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Table 2 Clinical features

From: In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients

Feature Genotype 1 Genotype 3 P value*
Patients (n) 18 23 0.7§
Males, n (%) 13 (68) 15 (65) 1§
Females, n (%) 6 (32) 8 (35)  
Age (years -/+SD) 44.6 -/+13.2 43.2 -/+10.2 0.19
Risk factors, n (%)    
Injecting drug use 7 (39) 12 (52) 0.53§
Blood transfusion 4 (22) 2 (9) 0.03§
Anti-D immunoglobulin 4 (22) 0 (0) 0.38§
Not determined 3 (17) 9 (39) 0.17§
Liver enzyme levels    
ALT (IU/L -/+SD) 112.8 -/+122.6 107.4 -/+86.3 0.34
AST (IU/L -/+SD) 66.6 -/+54.8 69.2 -/+59.5 0.5
Leukocyte counts    
WCC (x 109/L -/+SD) 5.7 -/+2 6.4 -/+2.5 0.3
Neutrophils (x103/μl) 3.3 -/+1.4 3.4 -/+1.7 0.99
Lymphocytes (x103/μl) 1.8 -/+0.6 2.3 -/+1 0.06
Monocytes (x103/μl) 0.46 -/+0.13 0.6 -/+0.3 0.17
Viral load (x106 IU/ml -/+) SD) 5.6 -/+10.8 7.5 -/+1.3 0.31
IL-28B genotype n (%)    
CC 4 (22) 8 (35) 0.5§
CT/TT 10 (56) 9 (39) 0.36§
Not determined 4 (22) 6 (26) 1§
  1. *Comparison between G1 and G3 infected patients.
  2. §Fisher’s exact test.
  3. Mann–Whitney U test.
  4. ALT alanine aminotrasferase, AST aspartate aminotransferase, WCC white cell count.