Figure 4

Visual predictive checks of clozapine in plasma and brain and norclozapine in plasma. Visual predictive check of clozapine concentrations in plasma (A) and brain (B), and norclozapine concentrations in plasma (C) following a 10 mg/kg subcutaneous dose of clozapine. Norclozapine concentrations in brain following a 10 mg/kg subcutaneous dose of clozapine were not measureable. Dashed line is the median of observed concentrations, the shape represents the 90% predicted interval of the median, and the dots represent the observed concentrations.