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Table 1 Baseline clinical characteristics and renal parameters of patients with IgAN

From: Time-averaged albumin predicts the long-term prognosis of IgA nephropathy patients who achieved remission

Characteristics

Remission patients

Non-progression patients

Progression patients

P-value

 

(n = 369)

(n = 308)

(n = 61)

 

Age (years)

37.2 ± 12.3

37.0 ± 1.7

38.1 ± 3.9

NS

Gender: Female n (%)

185 (50.1)

160 (51.9)

25 (40.9)

NS

SBP (mm Hg)

123.8 ± 15.9

123.5 ± 2.3

125.0 ± 3.7

NS

DBP (mm Hg)

79.3 ± 9.5

79.2 ± 1.4

79.8 ± 2.8

NS

RBC (X 1012/L)

4.4 ± 0.5

4.4 ± 0.2

4.5 ± 0.3

NS

WBC (X 109/L)

7.2 ± 1.7

7.0 ± 0.3

7.8 ± 0.4

NS

Hb g/L

133.7 ± 18.8

134.3 ± 2.9

131.3 ± 5.4

NS

PLT (X 109/L)

209.7 ± 63.8

215.5 ± 10.8

191.6 ± 23.6

NS

ALB g/L

39.4 ± 5.5

39.9 ± 0.8

37.7 ± 1.5

NS

ALT IU/L

16.0 (12.0-20.5)

16.0 (13.0-22.0)

15.0 (11.0-19.0)

NS

AST U/L

19.7 ± 8.5

20.4 ± 1.7

17.5 ± 0.9

NS

TG mmol/L

1.6 (1.1-2.3)

1.56 (1.1-2.4)

1.9 (1.3-2.2)

NS

TC mmol/L

5.0 (4.3-6.0)

4.97 (4.3-6.0)

5.1 (4.5-5.9)

NS

HDL mmol/L

1.29 ± 0.5

1.3 ± 0.1

1.2 ± 0.1

NS

LDL mmol/L

3.35 ± 1.7

3.4 ± 0.3

3.1 ± 0.2

NS

FBG mmol/L

4.9 ± 0.5

4.93 ± 0.1

4.8 ± 0.2

NS

SCr μmol/L

91.3 ± 36.4

86.2 ± 4.7

112.8 ± 11.9

0.02

BUN mmol/L

6.1 ± 2.4

5.8 ± 0.3

7.7 ± 0.9

0.03

eGFR (ml/min/1.73 m2)

83.6 ± 28.4

87.7 ± 3.9

66.7 ± 7.8

0.03

UA μmol/L

337.0 (280.9-426.5)

327.5 (277.4-414.0)

370.0 (326.5-514.5)

NS

Ca mmol/L

2.3 ± 0.1

2.3 ± 0.02

2.3 ± 0.1

NS

P mmol/L

1.2 ± 0.2

1.23 ± 0.05

1.2 ± 0.04

NS

ESR mm/h

22.0 (10.0-34.0)

22.0 (9.0-34.0)

24.0 (11.0-33.0)

NS

IgA g/L

2.9 ± 0.9

2.8 ± 0.2

3.1 ± 0.2

NS

IgG g/L

12.3 ± 3.2

12.7 ± 0.6

11.4 ± 0.9

NS

IgM g/L

1.3 ± 0.8

1.4 ± 0.2

1.1 ± 0.2

NS

C3 g/L

1.05 ± 0.2

1.06 ± 0.04

1.0 ± 0.1

NS

UPE (g/d)

2.1 (1.2-3.2)

1.8 (1.2-3.1)

2.4 (2.0-3.6)

NS

uRBC /HP

28.4 (7.5-50.0)

29.1 (7.2-50.0)

14.0 (9.4-29.1)

NS

CKD stage n (%)

    

Stage 1

310 (84.0)

264 (85.7)

46 (75.4)

 

Stage 2

37 (10.0)

29 (9.4)

8 (13.1)

 

Stage 3

22 (6.0)

15 (4.9)

7 (11.5)

 

Stage 4

0

0

0

 

Stage 5

0

0

0

NS

Renal biopsy Lee’s classification n (%)

    

Grade I-II

13 (3.5)

13 (4.2)

0

 

Grade III

194 (52.6)

163 (52.9)

31 (50.8)

 

Grade IV

131 (35.5)

107 (34.7)

24 (39.3)

 

Grade V

31 (8.4)

25 (8.2)

6 (9.9)

NS

  1. Values are given as the means ± standard deviation (SD) if the variables showed a normal distribution and as medians (IQR) if the variables did not show a normal distribution; n (%) was used for the categorical variables.
  2. SBP: systolic blood pressure; DBP: diastolic blood pressure; RBC: blood erythrocytes; WBC: blood leukocytes; Hb: hemoglobin; PLT: thrombocytes; ALB: serum albumin; ALT: glutamic-pyruvic transaminase; AST: glutamic-oxaloacetic transaminase; TG: triglyceride levels; TC: Serum total cholesterol levels; HDL: high density lipoprotein; LDL: low density lipoprotein; FBG: fasting blood glucose; SCr: serum creatinine; BUN: blood urea nitrogen; eGFR: estimated glomerular filtration rate; UA: serum uric acid; Ca: serum calcium levels; P: serum inorganic phosphorus levels; ESR: erythrocyte sedimentation rate; IgA, IgG, IgM: serum immunoglobulin levels; C3: complement 3 levels; UPE: 24-h urinary protein excretion; uRBC/HP: hematuria.
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Journal of Translational Medicine

ISSN: 1479-5876

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