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Table 3 Datasets analyzed by RCR used as negative controls

From: A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

Dataset name

Dataset ID

PubMed ID

Species

Experimental context

Tissue/cell type

Perturbation

Time point

Independent endpoint

Control

Hs_NHBE_CDKinh_rel_vs_blk_8 h

E-MTAB-1272

23926424

Hs

in vitro

NHBE

Exposure to CDK4/6 inhibitor

24 exposure + 8 h after removal of inhibitor

FACS, cell cycle analysis

Untreated

Hs_MVEC-C_hpx_vs_ct_24 h

GSE11341

18469115

Hs

In vitro

Primary cardiac microvascular ECs

24 h hypoxia (1% O2)

  

Normoxia (21% O2)

Hs_MVEC-L_hpx_vs_ct_24 h

GSE11341

18469115

Hs

In vitro

Primary human pulmonary microvascular ECs

24 h hypoxia (1% O2)

  

Normoxia (21% O2)

Hs_JurkT_ars_vs_ct

GSE46909

23824090

Hs

In vitro

Jurkat T cells

Arsenic trioxide 3 μM

6 h exposure

 

Untreated

  1. Hs_NHBE_CDKinh_rel_vs_blk_8h, Hs_MVEC-C_hpx_vs_ct_24h, Hs_MVEC-L_hpx_vs_ct_24h and Hs_JurkT_ars_vs_ct were used as a negative control datasets. ECs: endothelial cells; HAECs: human aortic endothelial cells; HCAECs: human coronary artery ECs; GFP: green fluorescent protein; OxPAPC: oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine; oxLDL: oxidized low density lipoprotein; IHS: immunohistochemistry; FACS: fluorescence-activated cell sorting; eQTL: expression quantitative trait loci; Hs: homo sapiens; IMA: internal mammary artery; Mm: mus musculus, MVECs: microvascular ECs; NHBE: normal human bronchial epithelial cells; h: hours; d: days; wk: weeks; yr: years.