Calculation of V-IPN coverage and odds ratio (OR). (A) Schematic representation of the subsets of HYPs in the SK, the network and a given dataset. (B) To ascertain the validity of the predictions, two statistical metrics, sensitivity (coverage) and OR, were estimated using HYPs data as depicted in the 2x2 table. (C) Coverage is an estimate of the fraction of possible HYPs in a subnetwork that are significant in a given dataset (A∩B/B), whereas the OR is the odds of having significant dataset HYPs in the network (a/b) divided by the odds of having non-significant dataset HYPs (c/d). Coverage is a measure of HYP enrichment within a given subnetwork, whereas OR reflects the probability of having significant dataset HYPs in that subnetwork. An OR higher than 1 implies that the odds of having significant HYPs in a given subnetwork are higher than the odds of having not significant HYPs in that subnetwork. Thus, OR estimates the odds of HYP enrichment. (D) Calculated coverage and OR for the entire V-IPN. Mm_Ao_78w_ApoE_vs_wt (GSE10000) is included as a building dataset reference. V-IPN: Vascular Inflammatory Process Network, Se: sensitivity, Cov: coverage.