Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

Table 4 Haemodynamic function in coronary artery ligation (CAL) and sham-operated (SO) Iso/Ade groups of hearts

Parameters	Pre-Ischaemia (n = 20)	Reperfusion (Percentage preischaemic value)
Parameters	Pre-Ischaemia (n = 20)	Control SO (n = 5)		Iso/Ade SO (n = 5)	Control CAL (n = 5)	Iso/Ade CAL (n = 5)
LVDP (mmHg)	75.2 ± 4.3	% of initial values	24.1 ± 3.9	65.4 ± 9.1 *	20.7 ± 4.0	69.6 ± 15.2 **
HR (beat/min)	271.1 ± 7.8		89.1 ± 19.4	107.5 ± 7.6	94.4 ± 3.0	99.0 ± 4.5
RPP (mmHg · beat/min)	20454 ± 1333		22.5 ± 5.9	66.3 ± 9.8 *	19.7 ± 4.0	69.0 ± 16.3 *
+dP/dt (mmHg/s)	2596 ± 154		31.7 ± 3.3	82.4 ± 20.8	66.3 ± 15.8	87.2 ± 14.3
-dP/dt (mmHg/s)	−1868 ± 138		37.8 ± 2.7	86.5 ± 22.1 **	40.4 ± 4.5	77.0 ± 14.3
Maximal LVEDP at Reperfusion (mmHg)	-	91.9 ± 19.1		28.7 ± 12.2 *	67.3 ± 9.9	20.2 ± 21.1

Haemodynamic function was determined at the end of equilibration period prior to ischaemia and after 60 min reperfusion. The perfusion protocol of Iso/Ade groups in this series of experiments was similar to that of Iso/Ade-0 group in Experimental Series 1.
* P < 0.05, ** P < 0.01 vs. a corresponding Control.

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