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Table 4 Haemodynamic function in coronary artery ligation (CAL) and sham-operated (SO) Iso/Ade groups of hearts

From: Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

Parameters Pre-Ischaemia (n = 20) Reperfusion (Percentage preischaemic value)
Control SO (n = 5) Iso/Ade SO (n = 5) Control CAL (n = 5) Iso/Ade CAL (n = 5)
LVDP (mmHg) 75.2 ± 4.3 % of initial values 24.1 ± 3.9 65.4 ± 9.1 * 20.7 ± 4.0 69.6 ± 15.2 **
HR (beat/min) 271.1 ± 7.8 89.1 ± 19.4 107.5 ± 7.6 94.4 ± 3.0 99.0 ± 4.5
RPP (mmHg · beat/min) 20454 ± 1333 22.5 ± 5.9 66.3 ± 9.8 * 19.7 ± 4.0 69.0 ± 16.3 *
+dP/dt (mmHg/s) 2596 ± 154 31.7 ± 3.3 82.4 ± 20.8 66.3 ± 15.8 87.2 ± 14.3
-dP/dt (mmHg/s) −1868 ± 138   37.8 ± 2.7 86.5 ± 22.1 ** 40.4 ± 4.5 77.0 ± 14.3
Maximal LVEDP at Reperfusion (mmHg) - 91.9 ± 19.1 28.7 ± 12.2 * 67.3 ± 9.9 20.2 ± 21.1
  1. Haemodynamic function was determined at the end of equilibration period prior to ischaemia and after 60 min reperfusion. The perfusion protocol of Iso/Ade groups in this series of experiments was similar to that of Iso/Ade-0 group in Experimental Series 1.
  2. * P < 0.05, ** P < 0.01 vs. a corresponding Control.