Figure 3

Anti-Id, anti-phage and anti-KLH-specific IgG responses. (A) Id-specific antibody response of patients 7–10 having received 1.25 mg phage Id vaccine. Patients’ sera were obtained shortly before each vaccination (day 1, 7, 14, 28, 56 and 84) and examined by ELISA using anti-Id antibodies. (B) Anti-Id specific immunoglobulin subtypes and anti-phage specific immunoglobulin subtypes (C) in patient 7 at day 28 after immunization with 1.25 mg phage Id vaccine. The results are representative for patients, who had raised and analyzed Id-specific antibodies (patients 7–10). (D) Antibody response to KLH (left) and wild type phage (right). Serum was taken shortly before each vaccination (day 1, 7, 14, week 4, 8, 12). Results of patient 2, having received 0.25 mg phage Id vaccination, are shown.