Table 2 Frequency of BRAF somatic mutations according to patients’ characteristics
From: Discrepant alterations in main candidate genes among multiple primary melanomas
Subgroups | (No. of samples) | Cases positive to BRAF mutations | ||
|---|---|---|---|---|
No. | % | P | ||
All samples | (229) | 109 | 47.6 | Â |
Sex | Â | Â | ||
 Male | (107) | 50 | 46.7 | 0.809 |
 Female | (122) | 59 | 48.4 | |
Site of primary melanoma | Â | Â | ||
 Head-neck | (20) | 9 | 45.0 | 0.623 |
 Trunk | (129) | 58 | 44.9 | |
 Limbs | (86) | 42 | 48.8 | |
Number of primary tumors | Â | Â | ||
 2 melanomas (186) |  | 86 | 46.2 | 0.172 |
 ≥ 3 melanomas (43) |  | 23 | 53.5 | |
Type of melanoma | Â | Â | ||
 Synchronous | (40) | 18 | 45.0 | 0.208 |
 Asynchronous | (189) | 91 | 48.1 | |
AJCC disease stage | Â | Â | ||
 ≤ I | (161) | 72 | 44.7 | 0.276 |
 ≥ II | (78) | 37 | 47.4 | |
Age at diagnosis | Â | Â | ||
 < 40 years | (34) | 18 | 52.9 | 0.089 |
 40-50 years | (52) | 25 | 48.1 | |
 > 50 years | (143) | 66 | 46.2 | |
Family history of melanoma | Â | Â | ||
1 affected members | (193) | 92 | 47.7 | 0.962 |
≥ 2 affected members | (36) | 17 | 47.2 | |