Illustrating the time course of the critical limb ischemia (CLI) in one patient. A) Indicated the wound appearance prior to treatment. B) Illustrated the wound situation by one week after debridement and combined therapy with clopidogrel and cilostazol treatment. C) Indicated the wound situation at one month after the treatment. D) Indicated wound situation by day 90 after the treatment. E) The result of magnetic resonance angiography image (MRA) prior to the combined therapy with clopidogrel and cilostazol showed the poor blood flow and total occlusion of arteries at the level just above the right ankle joint (red arrows). F) By day 90 after the combination therapy, the results of MRA showed that the new angiogenesis/small vessel density and collateral circulations were found to be present (red arrows).