| | |
PIK3CA
|
P value
|
PIK3CB
|
P value
|
PIK3CD
|
P value
|
PIK3CG
|
P value
|
|---|
|
Total no. of patients
|
60
| | | | | | | | |
|
Sex
| | | | | | | | | |
|
Male
|
39
|
5 (12.8)
|
0.298
|
7 (17.9)
|
0.737
|
10 (25.6)
|
0.011
|
5 (12.8)
|
0.412
|
|
Female
|
21
|
5 (23.8)
| |
5 (23.8)
| |
0 (0)
| |
1 (4.8)
| |
|
Age, years
| | | | | | | | | |
|
<60 y
|
36
|
6 (16.7)
|
1.000
|
5 (13.9)
|
0.193
|
6 (16.7)
|
1.000
|
5 (13.9)
|
0.387
|
|
≥60 y
|
24
|
4 (16.7)
| |
7 (29.2)
| |
4 (16.7)
| |
1 (4.2)
| |
|
Primary site
| | | | | | | | | |
|
node
|
54
|
10 (18.5)
|
0.557
|
11 (20.4)
|
1.000
|
9 (16.7)
|
1.000
|
6 (11.1)
|
1.000
|
|
Perpheral node
|
6
|
0 (0)
| |
1 (16.7)
| |
1 (16.7)
| |
0 (0.0)
| |
|
B symptoms
| | | | | | | | | |
|
Absence
|
37
|
7 (18.9)
|
0.727
|
7 (18.9)
|
1.000
|
6 (16.2)
|
1.000
|
2 (5.4)
|
0.191
|
|
Presence
|
23
|
3 (13.0)
| |
5 (21.7)
| |
4 (17.4)
| |
4 (17.4)
| |
|
Bulky disease
| | | | | | | | | |
|
<10 cm
|
47
|
7 (14.9)
|
0.506
|
8 (17.0)
|
0.552
|
7 (14.9)
|
1.000
|
4 (8.5)
|
0.347
|
|
≥10 cm
|
4
|
1 (25.0)
| |
1 (25.0)
| |
0 (0)
| |
1 (25.0)
| |
|
Performance status
| | | | | | | | |
|
ECOG 0-1
|
50
|
8 (16.0)
|
1.000
|
8 (16.0)
|
1.000
|
7 (14.0)
|
0.125
|
6 (12.0)
|
1.000
|
|
ECOG 2-4
|
4
|
0 (0.0)
| |
1 (25.0)
| |
2 (50.0)
| |
0 (0)
| |
|
LDH
| | | | | | | | | |
|
<2*insitutioal ULN
|
30
|
6 (34.9)
|
0.715
|
6 (20.0)
|
1.000
|
6 (20.0)
|
0.117
|
3 (10.0)
|
1.000
|
|
>2*insitutioal ULN
|
24
|
3 (12.5)
| |
5 (20.8)
| |
1 (4.2)
| |
3 (12.5)
| |
|
Extranodal site
| | | | | | | | | |
|
≤1
|
50
|
9 (18.0)
|
1.000
|
11 (22.0)
|
0.571
|
7 (14.0)
|
1.000
|
6 (12.0)
|
1.000
|
|
>1
|
4
|
0 (0)
| |
0 (0.0)
| |
0 (0)
| |
0/4 (0)
| |
|
Stage
| | | | | | | | | |
|
I/II
|
29
|
3 (10.3)
|
0.161
|
3 (10.3)
|
0.087
|
4 (13.8)
|
1.000
|
1 (3.4)
|
0.076
|
|
III/IV
|
23
|
6 (26.1)
| |
7 (30.4)
| |
3 (13.0)
| |
5 (21.7)
| |
|
IPI
| | | | | | | | | |
|
0-1
|
30
|
5 (16.7)
|
1.000
|
4 (13.3)
|
0.198
|
4 (13.3)
|
1.000
|
4 (13.3)
|
0.678
|
|
2-5
|
25
|
4 (16.0)
| |
7 (28.0)
| |
4 (16.0)
| |
2 (8.0)
| |
|
Pathology
| | | | | | | | | |
|
GCB
|
26
|
2 (76.9)
|
0.163
|
3 (11.5)
|
0.152
|
5 (19.2)
|
0.733
|
3 (11.5)
|
1.000
|
|
non-GCB
|
34
|
8 (23.5)
| |
9 (26.5)
| |
5 (14.7)
| |
3 (8.8)
| |
-
DLBCL diffuse large B-cell lymphoma, GCB germinal center B cell, IPI international prognostic index, LDH lactate dehydrogenase.
