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Table 6 CNV of PI3K subunits in 60 patients with DLBCLs by Nanostring nCounter analysis

From: Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma

   PIK3CA P value PIK3CB P value PIK3CD P value PIK3CG P value
Total no. of patients 60         
 Sex          
 Male 39 5 (12.8) 0.298 7 (17.9) 0.737 10 (25.6) 0.011 5 (12.8) 0.412
 Female 21 5 (23.8)   5 (23.8)   0 (0)   1 (4.8)  
Age, years          
<60 y 36 6 (16.7) 1.000 5 (13.9) 0.193 6 (16.7) 1.000 5 (13.9) 0.387
≥60 y 24 4 (16.7)   7 (29.2)   4 (16.7)   1 (4.2)  
Primary site          
 node 54 10 (18.5) 0.557 11 (20.4) 1.000 9 (16.7) 1.000 6 (11.1) 1.000
Perpheral node 6 0 (0)   1 (16.7)   1 (16.7)   0 (0.0)  
B symptoms          
 Absence 37 7 (18.9) 0.727 7 (18.9) 1.000 6 (16.2) 1.000 2 (5.4) 0.191
 Presence 23 3 (13.0)   5 (21.7)   4 (17.4)   4 (17.4)  
Bulky disease          
<10 cm 47 7 (14.9) 0.506 8 (17.0) 0.552 7 (14.9) 1.000 4 (8.5) 0.347
≥10 cm 4 1 (25.0)   1 (25.0)   0 (0)   1 (25.0)  
Performance status         
 ECOG 0-1 50 8 (16.0) 1.000 8 (16.0) 1.000 7 (14.0) 0.125 6 (12.0) 1.000
 ECOG 2-4 4 0 (0.0)   1 (25.0)   2 (50.0)   0 (0)  
LDH          
<2*insitutioal ULN 30 6 (34.9) 0.715 6 (20.0) 1.000 6 (20.0) 0.117 3 (10.0) 1.000
>2*insitutioal ULN 24 3 (12.5)   5 (20.8)   1 (4.2)   3 (12.5)  
Extranodal site          
≤1 50 9 (18.0) 1.000 11 (22.0) 0.571 7 (14.0) 1.000 6 (12.0) 1.000
>1 4 0 (0)   0 (0.0)   0 (0)   0/4 (0)  
Stage          
I/II 29 3 (10.3) 0.161 3 (10.3) 0.087 4 (13.8) 1.000 1 (3.4) 0.076
III/IV 23 6 (26.1)   7 (30.4)   3 (13.0)   5 (21.7)  
IPI          
 0-1 30 5 (16.7) 1.000 4 (13.3) 0.198 4 (13.3) 1.000 4 (13.3) 0.678
 2-5 25 4 (16.0)   7 (28.0)   4 (16.0)   2 (8.0)  
Pathology          
 GCB 26 2 (76.9) 0.163 3 (11.5) 0.152 5 (19.2) 0.733 3 (11.5) 1.000
 non-GCB 34 8 (23.5)   9 (26.5)   5 (14.7)   3 (8.8)  
  1. DLBCL diffuse large B-cell lymphoma, GCB germinal center B cell, IPI international prognostic index, LDH lactate dehydrogenase.