Table 6 CNV of PI3K subunits in 60 patients with DLBCLs by Nanostring nCounter analysis
| Â | Â | PIK3CA | P value | PIK3CB | P value | PIK3CD | P value | PIK3CG | P value |
|---|---|---|---|---|---|---|---|---|---|
Total no. of patients | 60 | Â | Â | Â | Â | Â | Â | Â | Â |
 Sex |  |  |  |  |  |  |  |  |  |
 Male | 39 | 5 (12.8) | 0.298 | 7 (17.9) | 0.737 | 10 (25.6) | 0.011 | 5 (12.8) | 0.412 |
 Female | 21 | 5 (23.8) |  | 5 (23.8) |  | 0 (0) |  | 1 (4.8) |  |
Age, years | Â | Â | Â | Â | Â | Â | Â | Â | Â |
<60 y | 36 | 6 (16.7) | 1.000 | 5 (13.9) | 0.193 | 6 (16.7) | 1.000 | 5 (13.9) | 0.387 |
≥60 y | 24 | 4 (16.7) |  | 7 (29.2) |  | 4 (16.7) |  | 1 (4.2) |  |
Primary site | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 node | 54 | 10 (18.5) | 0.557 | 11 (20.4) | 1.000 | 9 (16.7) | 1.000 | 6 (11.1) | 1.000 |
Perpheral node | 6 | 0 (0) | Â | 1 (16.7) | Â | 1 (16.7) | Â | 0 (0.0) | Â |
B symptoms | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Absence | 37 | 7 (18.9) | 0.727 | 7 (18.9) | 1.000 | 6 (16.2) | 1.000 | 2 (5.4) | 0.191 |
 Presence | 23 | 3 (13.0) |  | 5 (21.7) |  | 4 (17.4) |  | 4 (17.4) |  |
Bulky disease | Â | Â | Â | Â | Â | Â | Â | Â | Â |
<10 cm | 47 | 7 (14.9) | 0.506 | 8 (17.0) | 0.552 | 7 (14.9) | 1.000 | 4 (8.5) | 0.347 |
≥10 cm | 4 | 1 (25.0) |  | 1 (25.0) |  | 0 (0) |  | 1 (25.0) |  |
Performance status | Â | Â | Â | Â | Â | Â | Â | Â | |
 ECOG 0-1 | 50 | 8 (16.0) | 1.000 | 8 (16.0) | 1.000 | 7 (14.0) | 0.125 | 6 (12.0) | 1.000 |
 ECOG 2-4 | 4 | 0 (0.0) |  | 1 (25.0) |  | 2 (50.0) |  | 0 (0) |  |
LDH | Â | Â | Â | Â | Â | Â | Â | Â | Â |
<2*insitutioal ULN | 30 | 6 (34.9) | 0.715 | 6 (20.0) | 1.000 | 6 (20.0) | 0.117 | 3 (10.0) | 1.000 |
>2*insitutioal ULN | 24 | 3 (12.5) | Â | 5 (20.8) | Â | 1 (4.2) | Â | 3 (12.5) | Â |
Extranodal site | Â | Â | Â | Â | Â | Â | Â | Â | Â |
≤1 | 50 | 9 (18.0) | 1.000 | 11 (22.0) | 0.571 | 7 (14.0) | 1.000 | 6 (12.0) | 1.000 |
>1 | 4 | 0 (0) | Â | 0 (0.0) | Â | 0 (0) | Â | 0/4 (0) | Â |
Stage | Â | Â | Â | Â | Â | Â | Â | Â | Â |
I/II | 29 | 3 (10.3) | 0.161 | 3 (10.3) | 0.087 | 4 (13.8) | 1.000 | 1 (3.4) | 0.076 |
III/IV | 23 | 6 (26.1) | Â | 7 (30.4) | Â | 3 (13.0) | Â | 5 (21.7) | Â |
IPI | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0-1 | 30 | 5 (16.7) | 1.000 | 4 (13.3) | 0.198 | 4 (13.3) | 1.000 | 4 (13.3) | 0.678 |
 2-5 | 25 | 4 (16.0) |  | 7 (28.0) |  | 4 (16.0) |  | 2 (8.0) |  |
Pathology | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 GCB | 26 | 2 (76.9) | 0.163 | 3 (11.5) | 0.152 | 5 (19.2) | 0.733 | 3 (11.5) | 1.000 |
 non-GCB | 34 | 8 (23.5) |  | 9 (26.5) |  | 5 (14.7) |  | 3 (8.8) |  |