Table 1 Clinical, demographic and biochemical characteristics

Age [years, median (IQR)]

62 (59–66)

Females (%)

52.6

Current smoker (%)

7.7

Current alcohol use (%)

72.2

Body mass index [Kg/m², median (IQR)]

28.0 (25.7-31.2)

Daily number of steps [median (IQR)]

6,903 (4,718-8,824)

Systolic blood pressure (mmHg, mean±SD)

135±16

Diastolic blood pressure (mmHg, mean±SD)

80±10

Heart rate (b/min, mean±SD)

66±10

Hypertension (%)

43.8

Rheumatoid arthritis (%)

5.2

Diabetes (%)

1.7

Hypercholesterolaemia (%)

36.7

Cardiovascular risk score [%, median (IQR)]

7 (4–10)

Low (%)

70.9

Moderate (%)

22.5

High (%)

6.6

Non steroidal anti-inflammatory drugs (%)

8.9

Beta-blockers (%)

17.0

Angiotensin converting enzyme inhibitors (%)

42.2

Calcium-channel blockers (%)

9.6

Statins (%)

28.1

Diuretics (%)

10.0

Antidiabetic drugs (%)

1.5

Folic acid supplements (%)

1.4

Fasting serum glucose [mmol/L, median (IQR)]

4.8 (4.4-5.2)

Total cholesterol (mmol/L, mean±SD)

5.2±0.9

LDL-cholesterol (mmol/L, mean±SD)

3.2±0.8

HDL-cholesterol [mmol/L, median (IQR)]

1.3 (1.1-1.5)

Triglycerides [mmol/L, median (IQR)]

1.1 (0.8-1.6)

eGFR^a (mL/min, mean±SD)

81±16

C-reactive protein [mg/L, median (IQR)]

1.9 (1.2-3.5)

Homocysteine [μmol/L, median (IQR)]

8.8 (7.6-10.5)

Cysteine (μmol/L, mean±SD)

183.1±36.5

Taurine [μmol/L, median (IQR)]

62.0 (51.6-83.6)

Glutamylcysteine (μmol/L, mean±SD)

4.2±1.1

Glutathione [μmol/L, median (IQR)]

3.9 (3.0-5.2)

Cysteinylglycine [μmol/L, median (IQR)]

28.6 (25.2-32.9)