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Table 4 The sensitivity and specificity of five gene expression levels for the prediction of irinotecan sensitivity

From: A three-gene signature as potential predictive biomarker for irinotecan sensitivity in gastric cancer

Genes Chemotheraputic agents Sensitivity Specificity AUC (95% CI) P
APTX Irinotecan 73% 74% 0.758 (0.669-0.847) <0.001
BRCA1 Irinotecan 91% 58% 0.760 (0.673-0.846) < 0.001
ERCC1 Irinotecan 64% 79% 0.726 (0.632-0.821) <0.001
ISG15 Irinotecan 59% 73% 0.617 (0.494-0.740) 0.047
Topo1 Irinotecan 48% 94% 0.664 (0.563-0.765) 0.002