Table 4 The sensitivity and specificity of five gene expression levels for the prediction of irinotecan sensitivity
Genes | Chemotheraputic agents | Sensitivity | Specificity | AUC (95% CI) | P |
|---|---|---|---|---|---|
APTX | Irinotecan | 73% | 74% | 0.758 (0.669-0.847) | <0.001 |
BRCA1 | Irinotecan | 91% | 58% | 0.760 (0.673-0.846) | < 0.001 |
ERCC1 | Irinotecan | 64% | 79% | 0.726 (0.632-0.821) | <0.001 |
ISG15 | Irinotecan | 59% | 73% | 0.617 (0.494-0.740) | 0.047 |
Topo1 | Irinotecan | 48% | 94% | 0.664 (0.563-0.765) | 0.002 |