| Promoter methylation | Protein expression | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Variable without interaction term | ||||||
  Gender | 0.83 | 0.41-1.52 | 0.44 | 0.95 | 0.46-1.76 | 0.86 |
  Age | 1.10 | 1.01-1.20 | 0.002 | 1.10 | 1.01-1.12 | 0.002 |
  Performance status | 0.98 | 0.92-1.02 | 0.001 | 0.98 | 0.92-1.02 | 0.001 |
  Extent of surgery | 0.14 | 0.08-0.22 | < 0.001 | 0.14 | 0.08-0.24 | < 0.001 |
  MGMT promoter | 1.32 | 1.11-1.56 | 0.012 | 1.32 | 1.11-1.55 | 0.012 |
  TMZ therapy | 0.29 | 0.14-0.50 | < 0.001 | 0.29 | 0.14-0.49 | < 0.001 |
  Promoter methylation | 0.62 | 0.31-1.19 | 0.15 |  |  |  |
  Protein expression |  |  |  | 2.11 | 1.09-3.77 | 0.02 |
Variable with interaction terms | ||||||
  Gender | 0.83 | 0.41-1.55 | 0.46 | 1.02 | 0.50-1.87 | 0.95 |
  Age | 1.10 | 1.01-1.20 | 0.002 | 1.10 | 1.01-1.22 | 0.001 |
  Performance status | 0.98 | 0.92-1.03 | 0.002 | 0.98 | 0.92-1.02 | 0.001 |
  Extent of surgery | 0.14 | 0.08-0.22 | < 0.001 | 0.14 | 0.08-0.34 | < 0.001 |
  MGMT promoter | 1.32 | 1.11-1.57 | 0.018 | 1.32 | 1.11-1.55 | 0.012 |
  TMZ therapy | 0.32 | 0.11-0.83 | 0.02 | 0.11 | 0.03-0.25 | < 0.001 |
  Promoter methylation | 0.67 | 0.59-2.91 | 0.33 |  |  |  |
  Protein expression |  |  |  | 1.06 | 0.45-2.11 | 0.45 |
  Promoter methylation × TMZ therapy |  |  | 0.83 |  |  |  |
  Protein expression × TMZ therapy |  |  |  |  |  | 0.004 |