Figure 1

Differential miRNA expression in 12 breast cancer cell lines. (A) A volcano plot shows that 19 out of 847 miRNAs were differentially expressed (p < 0.01 and fold-change >2). 11 miRNAs (labeled) have an average fold-change above 10 between aggressive and less-aggressive groups. (B) Heatmap representing the expression values of 11 miRNAs that are differentially expressed between aggressive and less aggressive groups. (C) qRT-PCR confirmation of the miRNA array results for miR-200c, miR-205, miR-375, and miR-146a in the 12 breast cell lines.