Figure 2

Effects of Selectikine treatment on peripheral CD4⁺and CD8⁺T-cells. (A) Absolute counts (cells/mm³) and frequencies (%) of CD3⁺CD4⁺ and CD3⁺CD8⁺ T-cells (gated on lymphocytes using FSC/SSC parameters) on days 1 and 8 during the first and second treatment cycles. Graphs show the individual values of 39 patients treated with 0.075 to 0.9 mg/kg Selectikine alone. Bars represent geometric mean values, with 95% CI. (B) CD4⁺/CD8⁺ ratios on days 1 and 8 during the first and second treatment cycles. Box-and-whiskers graphs show geometric mean with 95% CI. (C) Serum concentrations (ng/mL) of soluble interleukin-2 receptor on days 1 and 3 during the first and second treatment cycle. The box and whisker graph shows geometric mean values per dose-group. *P < 0.05, **P ≤ 0.01, ***P ≤ 0.005.