Table 2 Conservancy of neuraminidase (NA) epitopes of sH1N1 and pH1N1 influenza viruses
NA sequence epitopea | Number (%) of study years conservedb | Epitope id in IEDB | Possible B-cell epitopec | Possible MHC I allelesd | Possible MHC II allelese |
|---|---|---|---|---|---|
KDNSIRIGSKGDVFVIR | 99.8 | 129048 | SIRIGSKGDV(105–114) | A*0201,A*03, | DRB1*0101,DRB1*0301,DRB1*0401 |
(102–118) |  |  | DNSIRIGSKGDVFV(103–116) | A*1101 | DRB1*0701,DRB1*1101,DRB1*1501 |
IGSKGDVFVIREPFIS | 99.8 | 128924 | GDVFVIREPF(112–121) | A*0201,A*03, A*1101 | DRB1*1101,DRB1*1501, |
RTFFLTQGALLNDKHSN | 99.5 | 127810 | FLTQGALLND(133–142) | A*01,A*03, | DRB1*0101,DRB1*0301,DRB1*0401 |
(130–146) |  |  | FFLTQGALLNDKHS(132–145) | A*1101 | DRB1*0701,DRB1*1101,DRB1*1501 |
ISGPDNGAVAVLKYNGI | 99.5 | 128994 | ISGPDNGAVAVLKY(195–208) | A*01,A*0201 | DRB1*0301,DRB1*0401,DRB1*1501 |
(195–211) |  |  | GPDNGAVAVL(197–206) |  |  |
VCRDNWHGSNRPWVSFN | 99.9 | 130190 | CRDNWHGSNRPW(292–303) | A*01 | DRB1*0101,DRB1*0401,DRB1*0701, |
(291–307) |  |  | RDNWHGSNRPWVSF(293–306) |  | DRB1*1101 |
WSGYSGSFVQHPELTGL | 99.9 | 130342 | * | A*0201,A*03, | DRB1*0101,DRB1*0401,DRB1*0701, |
(399–415) |  |  |  | A*1101 | DRB1*1101,DRB1*1501, |
SFVQHPELTGLDCIRP | 99.2 | 129889 | * | A*01, A*0201, | DRB1*0101,DRB1*0401,DRB1*1501 |
(405–420) |  |  |  | A*03, A*1101 |  |
PELTGLDCIRPCFWVEL | 99.3 | 129560 | * | A*01,A*0201, | DRB1*0101,DRB1*0301,DRB1*0401 |
(410–426) |  |  |  | A*03,A*1101 | DRB1*0701,DRB1*1101,DRB1*1501 |