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Table 1 Conservancy of hemagglutinin (HA) epitopes of sH1N1 and pH1N1 influenza viruses

From: Highly conserved antigenic epitope regions of hemagglutinin and neuraminidase genes between 2009 H1N1 and seasonal H1N1 influenza: vaccine considerations

 HA sequence epitopea

Number (%) of study years conservedb

Epitope id in IEDB

Possible B-cell epitopec

Possible MHC I allelesd

Possible MHC II allelese

IGYHANNSTDTVDTVLEK

99.9

95458

IGYHANNSTD(22–31)

A*01,A*1101

DRB1*0101,DRB1*0301,DRB1*0401,

(22–39)

  

NSTDTVDTVL(28–37)

 

DRB1*0701, DRB1*1501

HANNSTDTVDTVLEKNV

99.9

128846

NSTDTVDTVL(28–37)

A*01,A*1101

DRB1*0101,DRB1*0301,DRB1*0401,

(25–41)

     

STDTVDTVLEKNVTVTHS

99.9

95880

STDTVDTVLEKNVTVTHS

A*01,A*0201,

DRB1*0101,DRB1*0301,DRB1*0401,

(29–46)

  

(29–46)

A*03,A*1101

DRB1*0701, DRB1*1101,DRB1*1501

DTVDTVLEKNVTVTHSV

99.8

128470

NSTDTVDTVL(28–37)

A*01,A*0201,

DRB1*0101,DRB1*0301,DRB1*0401,

(31–47)

  

DTVLEKNVTVTH(34–45)

A*03,A*1101

DRB1*0701, DRB1*1101,DRB1*1501

DYEELREQLSSVSSFER

99.8

128481

YEELREQLSSVSSF

A*01,A*0201

DRB1*0101,DRB1*0301,DRB1*0401,

(114–130)

  

(115–128)

A*03,A*1101

DRB1*0701, DRB1*1101,DRB1*1501

EQLSSVSSFERFE

99.8

113375

*

A*0201,A*03,

DRB1*0701

EQLSSVSSFERFEIFPK

99.9

128569

QLSSVSSFERFEIF

A*0201,A*03,

DRB1*0101,DRB1*0301,DRB1*0401,

(120–136)

  

(121–134)

A*1101

DRB1*0701, DRB1*1101,DRB1*1501

IQSRGLFGAIAGFIEGG

99.9

128979

SRGLFGAIAG

A*0201,A*03,

DRB1*0101,DRB1*0301,DRB1*0401,

(341–357)

  

(343–352)

A*1101

DRB1*0701,DRB1*1501

FGAIAGFIEGGWTGMVD

99.2

128623

AIAGFIEGGW

A*1101

DRB1*0101,DRB1*0301,DRB1*0401,

(347–363)

  

(349–358)

DRB1*0701

 

FIEGGWTGMVDGWYGYH

99.2

128629

EGGWTGMVDGWY(355–366)

A*1101

DRB1*0101,DRB1*0401,DRB1*0701,

(353–369)

  

EGGWTGMVDGWYGY(355–368)

 

DRB1*1501

TGMVDGWYGYHHQNEQG

99.2

130077

TGMVDGWYGYHH(359–370)

A*1101

DRB1*0101,DRB1*0301,DRB1*0401,

(359–375)

    

DRB1*0701,DRB1*1101,DRB1*1501

TGMVDGWYGYHHQNEQGS

99.2

95905

TGMVDGWYGYHH(359–370)

A*1101

DRB1*0101,DRB1*0301,DRB1*0401,

(359–376)

    

DRB1*0701,DRB1*1101,DRB1*1501

WYGYHHQNEQGSGYAAD

100.0

130354

YGYHHQNEQGSGYA

A*1101

DRB1*0101,DRB1*0401,DRB1*0701,

(365–381)

  

(366–379)

DRB1*1101

 

TNKVNSVIEKMNTQFTA

99.6

130108

TNKVNSVIEKMNTQFTAV

A*0201,A*1101

DRB1*0101,DRB1*0301,DRB1*0401,

(393–409)

  

(393–410)

 

DRB1*0701,DRB1*1101,DRB1*1501

NKVNSVIEKMNTQFTAVG

99.6

95623

*

A*1101

DRB1*0101,DRB1*0301,DRB1*0401,

(394–411)

    

DRB1*0701,DRB1*1101,DRB1*1501

SVIEKMNTQFTAV(398–410)

99.5

80042

*

A*0201,A*1101

DRB1*0101,DRB1*0401,DRB1*1501

SVIEKMNTQFTAVGKE(398–413)

99.

127161

   

VIEKMNTQFTAVGKEFN

99.4

130227

KMNTQFTAVGKEFN(402-415)

A*0201,A*1101

DRB1*0101,DRB1*0301,DRB1*0401

(399–415)

    

DRB1*0701,DRB1*1101,DRB1*1501

EKMNTQFTAVGKE(401–413)

99.9

7980

*

A*0201,A*03, A*1101

DRB1*0101,DRB1*0401,DRB1*1501

NLNKKVDDGFLDIWTYN

97.4

129494

*

A*01,A*0201,

DRB1*0101,DRB1*0301,DRB1*0401,

(423–439)

   

A*03,A*1101

DRB1*0701,DRB1*1501

DDGFLDIWTYNAELLVL

97.5

128403

DDGFLDIWTYNAEL(429–442)

A*01,A*0201,

DRB1*0101,DRB1*0301,DRB1*0401

(429–445)

   

A*03,A*1101

DRB1*0701,DRB1*1101,DRB1*1501

DGFLDIWTYNAELLV

97.1

113324

*

A*1101

DRB1*0101,DRB1*0301,DRB1*0401

(430–444)

    

DRB1*0701,DRB1*1101,DRB1*1501

IWTYNAELLVLLENERT

99.7

129015

WTYNAELLVLLENE(436–449)

A*01,A*0201,

DRB1*0101,DRB1*0301,DRB1*0401

(435–451)

   

A*03,A*1101

DRB1*0701,DRB1*1101,DRB1*1501

WTYNAELLVLLENERTLD

100.0

96007

WTYNAELLVLLENE(436–449)

A*01,A*0201,

DRB1*0101,DRB1*0301,DRB1*0401

(436–453)

   

A*03,A*1101

DRB1*0701,DRB1*1101,DRB1*1501

ELLVLLENERTLD 99.9

 

79809

*

A*0201,A*1101

DRB1*0101,DRB1*0301,DRB1*0401,

(441–453)

    

DRB1*0701,DRB1*1501

LKNNAKEIGNGCFEFYH

99.9

129255

KNNAKEIGNGCFEF(471–484)

A*01,A*03,

DRB1*0101,DRB1*0301,DRB1*0401,

(470–486)

   

A*1101

DRB1*0701

MESVKNGTYDYPKYSEE

99.8

129388

*

A*01,A*0201,

DRB1*0101,DRB1*0301,DRB1*0701,

(493–509)

   

A*03,A*1101

DRB1*1101,DRB1*1501

SLGAISFWMCSNGSLQ

99.7

129938

*

A*0201,A*03,

DRB1*0301,DRB1*0401, DRB1*1101,

(546–561)

   

A*1101

DRB1*1501

SFWMCSNGSLQCRICI

99.3

129890

*

A*1101

DRB1*0101,DRB1*0301,DRB1*0401,

(551–566)

    

DRB1*0701,DRB1*1501

  1. a. Epitopes in IEDB were experimentally identified epitopes in sH1N1 HA genes. b. The conservancy ratio of 1432 genes of sH1N1 HA sequences, whose strains isolated from 1968 to 2008. c. The B-cell epitopes of pH1N1 HA genes are predicted by ABCpred in 10 mer or more, respectively. d. MHC I alleles of 10 mer and more of pH1N1 HA genes are Predicted by BIMAS (explicit number = 100) and SYFPEITHI (score ≥10.0), respectively. The same epitope sequences predicted by both BIMAS and SYFPEITHI were determined. e. MHC II alleles of 10 mer and more of pH1N1 HA genes are predicted by SYFPEITHI (score ≥10.0), respectively.
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Journal of Translational Medicine

ISSN: 1479-5876

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