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Table 1 Conservancy of hemagglutinin (HA) epitopes of sH1N1 and pH1N1 influenza viruses

From: Highly conserved antigenic epitope regions of hemagglutinin and neuraminidase genes between 2009 H1N1 and seasonal H1N1 influenza: vaccine considerations

 HA sequence epitopea Number (%) of study years conservedb Epitope id in IEDB Possible B-cell epitopec Possible MHC I allelesd Possible MHC II allelese
IGYHANNSTDTVDTVLEK 99.9 95458 IGYHANNSTD(22–31) A*01,A*1101 DRB1*0101,DRB1*0301,DRB1*0401,
(22–39)    NSTDTVDTVL(28–37)   DRB1*0701, DRB1*1501
HANNSTDTVDTVLEKNV 99.9 128846 NSTDTVDTVL(28–37) A*01,A*1101 DRB1*0101,DRB1*0301,DRB1*0401,
(25–41)      
STDTVDTVLEKNVTVTHS 99.9 95880 STDTVDTVLEKNVTVTHS A*01,A*0201, DRB1*0101,DRB1*0301,DRB1*0401,
(29–46)    (29–46) A*03,A*1101 DRB1*0701, DRB1*1101,DRB1*1501
DTVDTVLEKNVTVTHSV 99.8 128470 NSTDTVDTVL(28–37) A*01,A*0201, DRB1*0101,DRB1*0301,DRB1*0401,
(31–47)    DTVLEKNVTVTH(34–45) A*03,A*1101 DRB1*0701, DRB1*1101,DRB1*1501
DYEELREQLSSVSSFER 99.8 128481 YEELREQLSSVSSF A*01,A*0201 DRB1*0101,DRB1*0301,DRB1*0401,
(114–130)    (115–128) A*03,A*1101 DRB1*0701, DRB1*1101,DRB1*1501
EQLSSVSSFERFE 99.8 113375 * A*0201,A*03, DRB1*0701
EQLSSVSSFERFEIFPK 99.9 128569 QLSSVSSFERFEIF A*0201,A*03, DRB1*0101,DRB1*0301,DRB1*0401,
(120–136)    (121–134) A*1101 DRB1*0701, DRB1*1101,DRB1*1501
IQSRGLFGAIAGFIEGG 99.9 128979 SRGLFGAIAG A*0201,A*03, DRB1*0101,DRB1*0301,DRB1*0401,
(341–357)    (343–352) A*1101 DRB1*0701,DRB1*1501
FGAIAGFIEGGWTGMVD 99.2 128623 AIAGFIEGGW A*1101 DRB1*0101,DRB1*0301,DRB1*0401,
(347–363)    (349–358) DRB1*0701  
FIEGGWTGMVDGWYGYH 99.2 128629 EGGWTGMVDGWY(355–366) A*1101 DRB1*0101,DRB1*0401,DRB1*0701,
(353–369)    EGGWTGMVDGWYGY(355–368)   DRB1*1501
TGMVDGWYGYHHQNEQG 99.2 130077 TGMVDGWYGYHH(359–370) A*1101 DRB1*0101,DRB1*0301,DRB1*0401,
(359–375)      DRB1*0701,DRB1*1101,DRB1*1501
TGMVDGWYGYHHQNEQGS 99.2 95905 TGMVDGWYGYHH(359–370) A*1101 DRB1*0101,DRB1*0301,DRB1*0401,
(359–376)      DRB1*0701,DRB1*1101,DRB1*1501
WYGYHHQNEQGSGYAAD 100.0 130354 YGYHHQNEQGSGYA A*1101 DRB1*0101,DRB1*0401,DRB1*0701,
(365–381)    (366–379) DRB1*1101  
TNKVNSVIEKMNTQFTA 99.6 130108 TNKVNSVIEKMNTQFTAV A*0201,A*1101 DRB1*0101,DRB1*0301,DRB1*0401,
(393–409)    (393–410)   DRB1*0701,DRB1*1101,DRB1*1501
NKVNSVIEKMNTQFTAVG 99.6 95623 * A*1101 DRB1*0101,DRB1*0301,DRB1*0401,
(394–411)      DRB1*0701,DRB1*1101,DRB1*1501
SVIEKMNTQFTAV(398–410) 99.5 80042 * A*0201,A*1101 DRB1*0101,DRB1*0401,DRB1*1501
SVIEKMNTQFTAVGKE(398–413) 99. 127161    
VIEKMNTQFTAVGKEFN 99.4 130227 KMNTQFTAVGKEFN(402-415) A*0201,A*1101 DRB1*0101,DRB1*0301,DRB1*0401
(399–415)      DRB1*0701,DRB1*1101,DRB1*1501
EKMNTQFTAVGKE(401–413) 99.9 7980 * A*0201,A*03, A*1101 DRB1*0101,DRB1*0401,DRB1*1501
NLNKKVDDGFLDIWTYN 97.4 129494 * A*01,A*0201, DRB1*0101,DRB1*0301,DRB1*0401,
(423–439)     A*03,A*1101 DRB1*0701,DRB1*1501
DDGFLDIWTYNAELLVL 97.5 128403 DDGFLDIWTYNAEL(429–442) A*01,A*0201, DRB1*0101,DRB1*0301,DRB1*0401
(429–445)     A*03,A*1101 DRB1*0701,DRB1*1101,DRB1*1501
DGFLDIWTYNAELLV 97.1 113324 * A*1101 DRB1*0101,DRB1*0301,DRB1*0401
(430–444)      DRB1*0701,DRB1*1101,DRB1*1501
IWTYNAELLVLLENERT 99.7 129015 WTYNAELLVLLENE(436–449) A*01,A*0201, DRB1*0101,DRB1*0301,DRB1*0401
(435–451)     A*03,A*1101 DRB1*0701,DRB1*1101,DRB1*1501
WTYNAELLVLLENERTLD 100.0 96007 WTYNAELLVLLENE(436–449) A*01,A*0201, DRB1*0101,DRB1*0301,DRB1*0401
(436–453)     A*03,A*1101 DRB1*0701,DRB1*1101,DRB1*1501
ELLVLLENERTLD 99.9   79809 * A*0201,A*1101 DRB1*0101,DRB1*0301,DRB1*0401,
(441–453)      DRB1*0701,DRB1*1501
LKNNAKEIGNGCFEFYH 99.9 129255 KNNAKEIGNGCFEF(471–484) A*01,A*03, DRB1*0101,DRB1*0301,DRB1*0401,
(470–486)     A*1101 DRB1*0701
MESVKNGTYDYPKYSEE 99.8 129388 * A*01,A*0201, DRB1*0101,DRB1*0301,DRB1*0701,
(493–509)     A*03,A*1101 DRB1*1101,DRB1*1501
SLGAISFWMCSNGSLQ 99.7 129938 * A*0201,A*03, DRB1*0301,DRB1*0401, DRB1*1101,
(546–561)     A*1101 DRB1*1501
SFWMCSNGSLQCRICI 99.3 129890 * A*1101 DRB1*0101,DRB1*0301,DRB1*0401,
(551–566)      DRB1*0701,DRB1*1501
  1. a. Epitopes in IEDB were experimentally identified epitopes in sH1N1 HA genes. b. The conservancy ratio of 1432 genes of sH1N1 HA sequences, whose strains isolated from 1968 to 2008. c. The B-cell epitopes of pH1N1 HA genes are predicted by ABCpred in 10 mer or more, respectively. d. MHC I alleles of 10 mer and more of pH1N1 HA genes are Predicted by BIMAS (explicit number = 100) and SYFPEITHI (score ≥10.0), respectively. The same epitope sequences predicted by both BIMAS and SYFPEITHI were determined. e. MHC II alleles of 10 mer and more of pH1N1 HA genes are predicted by SYFPEITHI (score ≥10.0), respectively.