Table 2 Comparison of hypermethylation detection on HNSCC tumor specimens and normal control salivary rinse samples
Genes | Control | HNSCC | Specificity% (95% CI) | Senstivity% (95% CI) | ||
|---|---|---|---|---|---|---|
Cases (n) | M n (%) | Cases (n) | M n (%) | |||
CCNA1 | 60 | 2 (3) | 67 | 22 (33) | 97 (93–101) | 33 (21–45) |
DAPK | 39 | 1 (3) | 68 | 35 (51) | 97 (93–101) | 51 (38–64) |
MGMT | 57 | 2 (4) | 67 | 14 (21) | 96 (91–101) | 21 (11–31) |
SFRP1 | 20 | 0 (0) | 58 | 36 (62) | 100 | 62 (50–74) |
TIMP3 | 60 | 2 (3) | 70 | 37 (53) | 97 (93–101) | 53 (40–66) |