Figure 4
Evaluation of bone related markers in different groups by semi-quantitative scoring were demonstrated. 0: no expression; 1: focal expression; 2: partial expression; 3: circumferential expression. Immunohistochemical result showed that CathepsinK, RANKL and Osteocalcin were abundantly expressed whereas Runx2 was moderately expressed (p < 0.01) in CRF rats. Expression of Runx2, CathepsinK, RANKL and Osteocalcin were significantly down regulated in 2%La group (p < 0.01 vs CRF group). OPG were strongly positive in Control group and significantly down regulated in CRF group (p < 0.01 vs Control group) and up-regulated in 2%La group (p < 0.05 vs CRF group).