Figure 4

Differentiation of all cancers from all inflammatory pathologies by miRNA biomarker pairs. The concentrations of miRNAs in plasma samples from patients with cancers of four organs (40 patients total) and three inflammatory diseases (30 patients total) were measured by RT-qPCR and the ratios of various miRNAs were calculated as 2^-ΔCq x 100. A, B – box-plots. C, D – Receiver-Operating Characteristic (ROC) curves of differentiation between patients with cancers of the four organs and patients with any of the three inflammatory diseases obtained with different biomarker pairs. All statistical analyses are performed as in Figure 1. E, F – 2D-graphs comparing biomarker miRNA pairs from A, C and B, D, respectively.