Figure 1

Effect of sildenafil treatment on the endothelial function of apoE^−/− mice. (A) Acetylcholine (ACh)-induced endothelium-dependent relaxation in aortic rings, comparing untreated apoE^−/− mice with wild-type (WT) control mice. (B) Effect of the treatment with sildenafil (40 mg/kg/day for 3 weeks) on ACh-induced vasodilation in apoE^−/− mice compared to untreated apoE^−/− and to WT mice. Values are the means ± SEM. *p < 0.05 vs. WT; ^#p < 0.05 vs. untreated apoE^−/− (two-way ANOVA).