Table 1 Distribution of risk factors in cases and rest of cohort
Characteristics | Rest of cohort n = 27514 | CRC cases n = 584 | p | beta-catenin + n = 304 (61.0%) | beta- catenin – n = 194 (39.0%) | p | Cyclin D1+ n = 400 (80.3%) | Cyclin D1 –n = 98 (19.7%) | p | p53 + n = 241 (48.3%) | p53 – n = 258 (51.7%) | p | MSI n = 71 (14.6%) | MSS n = 416 (85.4%) | p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sex | <0.001 | 0.863 | 0.226 | 0.722 | 0.057 | ||||||||||
Male (%) | 10783 (39.2) | 280 (47.9) | 145 (47.7) | 91 (46.9) | 185 (46.2) | 52 (53.1) | 112 (46.5) | 124 (48.1) | 26 (36.6) | 203 (48.8) | |||||
Female (%) | 16731 (60.8) | 304 (52.1) | 159 (52.3) | 103 (53.1) | 215 (53.8) | 46 (46.9) | 129 (53.5) | 134 (51.9) | 45 (63.4) | 213 | |||||
Age at baseline (years) | 58.0 | 61.8 | 61.9 | 62.0 | 62.3 | 60.2 | 61.5 | 62.3 | 64.4 | 61.5 | |||||
Male | 59.2 | 61.7 | <0.001 | 61.5 | 62.1 | 0.430 | 61.9 | 60.5 | 0.204 | 61.2 | 62.0 | 0.452 | 64.6 | 61.2 | 0.029 |
Female | 57.3 | 62.1 | <0.001 | 62.5 | 61.7 | 0.638 | 62.7 | 59.7 | 0.001 | 61.7 | 62.6 | 0.252 | 64.3 | 61.7 | 0.024 |
Smoking male (% ) | 0.104 | 0.749 | 0.371 | 0.199 | 0.793 | ||||||||||
Regularly | 2572 (25.5) | 53 (18.9) | 25 (17.2) | 17 (18.7) | 35 (18.9) | 8 (15.4) | 17 (15.2) | 24 (19.2) | 5 (19.2) | 38 (18.5) | |||||
Occasionally | 520 (4.8) | 12 (4.3) | 5 (3.4) | 3 (3.3) | 8 (4.3) | 0 | 5 (4.4) | 3 (2.4) | 1 (3.89 | 7 (3.4) | |||||
Former smoker | 4635 (43.0) | 145 (51.7) | 80 (55.2) | 44 (48.4) | 94 (51.4) | 31 (59.6) | 66 (58.9) | 60 (48.0) | 11 (42.3) | 107 (52.2) | |||||
Never smoker | 3046 (28.3) | 70 (25.0) | 35 (24.1) | 27 (29.7) | 48 (25.9) | 13 (25.0) | 24 (21.4) | 38 (30.4) | 9 (34.6) | 53 (25.9) | |||||
Smoking female (%) | 0.652 | 0.592 | 0.972 | 0.009 | 0.694 | ||||||||||
Regularly | 4976 (29.8) | 71 (23.4) | 36 (22.6) | 25 (24.3) | 49 (22.8) | 11 (23.9) | 26 (20.2) | 35 (26.1) | 12 (26.7) | 47 (22.1) | |||||
Occasionally | 722 (4.3) | 8 (2.6) | 3 (1.9) | 4 (3.9) | 7 (3.2) | 1 (2.2) | 2 (1.6) | 6 (4.5) | 1 (2.2) | 7 (3.3) | |||||
Former smoke | 4637 (27.7) | 87 (28.6) | 41 (25.7) | 30 (29.1) | 57 (26.5) | 13 (28.3) | 27 (20.9) | 43 (32.1) | 9 (20.0) | 59 (27.7) | |||||
Never smoker | 7386 (44.2) | 138 (45.4) | 79 (49.7) | 44 (42.7) | 102 (47.4) | 21 (45.7) | 74 (57.4) | 50 (37.3) | 23 (51.1) | 100 (46.9) | |||||
Level of education male (%) | 0.912 | 0.727 | 0.760 | 0.250 | 0.451 | ||||||||||
Not completed | 85 (0.8) | 2 (0.7) | 1 (0.7) | 0 | 1 (0.5) | 0 | 1 (0.9) | 0 | 0 | 1 (0.5) | |||||
6-8 years | 4852 (45.1) | 137 (48.9) | 76 (52.4) | 41 (45.1) | 93 (50.3) | 25 (48.1) | 57 (50.9) | 61 (48.8) | 13 (50.0) | 102 (49.8) | |||||
9-10 years | 2113 (19.6) | 55 (19.6) | 28 (19.3) | 21 (23.1) | 35 (18.9) | 14 (26.9) | 24 (21.4) | 25 (20.0) | 4 (15.4) | 44 (21.5) | |||||
10-12 years | 1279 (11.9) | 29 (10.4) | 16 (11.0) | 10 (11.0) | 21 (11.3) | 4 (7.7) | 7 (6.3) | 18 (14.4) | 6 (23.1) | 20 (9.8) | |||||
1 year university | 998 (9.3) | 19 (6.7) | 9 (6.2) | 5 (5.5) | 12 (6.5) | 2 (3.8) | 9 (8.0) | 5 (4.0) | 1 (3.8) | 13 (6.3) | |||||
University degree | 1424 (13.2) | 38 (13.6) | 15 (10.3) | 14 (15.4) | 23 (12.4) | 7 (13.5) | 14 (12.5) | 16 (12.8) | 2 (7.7) | 25 (12.2) | |||||
Level of education female (%) | 0.009 | 0.019 | 0.796 | 0.496 | 0.316 | ||||||||||
Not completed | 126 (0.8) | 3 (1.0) | 1 (0.6) | 2 (1.9) | 3 (1.4) | 0 | 2 (1.6) | 1 (0.7) | 0 | 3 (1.4) | |||||
6-8 years | 6419 (38.5) | 150 (49.8) | 88 (56.4) | 48 (46.6) | 111 (52.4) | 22 (47.8) | 73 (56.6) | 61 (46.2) | 25 (55.6) | 105 (50.0) | |||||
9-10 years | 5086 (30.5) | 75 (24.9) | 27 (17.3) | 35 (34.0) | 52 (24.5) | 12 (26.1) | 26 (20.2) | 38 (28.8) | 13 (28.9) | 50 (23.8) | |||||
10-12 years | 1161 (7.0) | 22 (7.3) | 15 (9.6) | 3 (2.9) | 13 (6.1) | 5 (10.9) | 9 (7.0) | 9 (6.8) | 0 | 18 (8.6) | |||||
1 year university | 1399 (8.4) | 26 (8.6) | 13 (8.3) | 9 (8.7) | 18 (8.5) | 3 (6.5) | 9 (7.8) | 13 (9.8) | 5 (11.1) | 18 (8.6) | |||||
University degree | 2496 (15.0) | 25 (8.3) | 12 (7.7) | 6 (5.8) | 15 (7.0) | 4 (8.7) | 9 (7.0) | 10 (7.5) | 2 (4.4) | 16 (7.5) | |||||
Alcohol (g/day) | |||||||||||||||
Male | 15.5 | 15.7 | 0.868 | 17.4 | 14.3 | 0.070 | 16.2 | 15.0 | 0.648 | 16.9 | 0.731 | 12.6 | 16.6 | 0.331 | |
Female | 7.7 | 6.2 | 0.002 | 6.3 | 5.8 | 0.583 | 6.0 | 6.7 | 0.968 | 6.2 | 5.9 | 0.626 | 4.6 | 6.2 | 0.310 |
Height (cm) | |||||||||||||||
Male | 176.4 | 176.3 | 0.400 | 176.1 | 176.9 | 0.392 | 176.3 | 176.9 | 0.773 | 176.8 | 176.0 | 0.329 | 176.4 | 176.3 | 0.817 |
Female | 163.6 | 163.3 | 0.220 | 162.8 | 163.6 | 0.179 | 163.4 | 162.6 | 0.394 | 162.2 | 164.2 | 0.006 | 163.1 | 163.3 | 0.620 |
Weight (kg) | |||||||||||||||
Male | 81.7 | 83.8 | 0.014 | 83.9 | 82.9 | 0.953 | 83.1 | 84.5 | 0.457 | 84.6 | 82.8 | 0.250 | 86.2 | 82.8 | 0.433 |
Female | 68.0 | 70.0 | 0.008 | 70.9 | 68.3 | 0.112 | 70.4 | 71.0 | 0.881 | 69.0 | 71.5 | 0.154 | 68.9 | 70.7 | 0.484 |
BMI (kg/m2) | |||||||||||||||
Male | 26.2 | 26.9 | <0.001 | 27.0 | 26.5 | 0.481 | 26.7 | 27.1 | 0.562 | 27.0 | 26.7 | 0.591 | 27.5 | 26.6 | 0.258 |
Female | 25.4 | 26.3 | 0.001 | 26.7 | 25.5 | 0.013 | 26.7 | 27.0 | 0.525 | 26.2 | 26.5 | 0.929 | 25.9 | 26.5 | 0.402 |
WHR (cm/cm) | |||||||||||||||
Male | 0.94 | 0.95 | 0.021 | 0.95 | 0.94 | 0.027 | 0.95 | 0.95 | 0.676 | 0.95 | 0.95 | 0.482 | 0.94 | 0.95 | 0.889 |
Female | 0.80 | 0.80 | 0.490 | 0.80 | 0.80 | 0.779 | 0.79 | 0.81 | 0.098 | 0.80 | 0.79 | 0.338 | 0.79 | 0.80 | 0.779 |
Waist (cm) | |||||||||||||||
Male | 94.0 | 96.3 | <0.001 | 96.6 | 94.9 | 0.424 | 95.6 | 96.8 | 0.575 | 96.9 | 95.4 | 0.427 | 96.6 | 95.5 | 0.586 |
Female | 77.9 | 80.1 | 0.001 | 80.9 | 78.8 | 0.215 | 79.9 | 81.9 | 0.299 | 79.9 | 80.7 | 0.839 | 79.0 | 80.6 | 0.494 |
Hip (cm) | |||||||||||||||
Male | 99.4 | 101.2 | <0.001 | 101.0 | 101.0 | 0.602 | 100.8 | 101.6 | 0.687 | 101.7 | 100.7 | 0.391 | 102.2 | 100.8 | 0.554 |
Female | 97.8 | 100.2 | <0.001 | 101.2 | 98.8 | 0.091 | 100.4 | 101.0 | 0.872 | 99.5 | 101.4 | 0.287 | 99.6 | 100.9 | 0.380 |