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Table 1 Distribution of risk factors in cases and rest of cohort

From: Influence of anthropometric factors on tumour biological characteristics of colorectal cancer in men and women: a cohort study

Characteristics Rest of cohort n = 27514 CRC cases n = 584 p beta-catenin + n = 304 (61.0%) beta- catenin – n = 194 (39.0%) p Cyclin D1+ n = 400 (80.3%) Cyclin D1 –n = 98 (19.7%) p p53 + n = 241 (48.3%) p53 – n = 258 (51.7%) p MSI n = 71 (14.6%) MSS n = 416 (85.4%) p
Sex    <0.001    0.863    0.226    0.722    0.057
 Male (%) 10783 (39.2) 280 (47.9)   145 (47.7) 91 (46.9)   185 (46.2) 52 (53.1)   112 (46.5) 124 (48.1)   26 (36.6) 203 (48.8)  
 Female (%) 16731 (60.8) 304 (52.1)   159 (52.3) 103 (53.1)   215 (53.8) 46 (46.9)   129 (53.5) 134 (51.9)   45 (63.4) 213  
Age at baseline (years) 58.0 61.8   61.9 62.0   62.3 60.2   61.5 62.3   64.4 61.5  
 Male 59.2 61.7 <0.001 61.5 62.1 0.430 61.9 60.5 0.204 61.2 62.0 0.452 64.6 61.2 0.029
 Female 57.3 62.1 <0.001 62.5 61.7 0.638 62.7 59.7 0.001 61.7 62.6 0.252 64.3 61.7 0.024
Smoking male (% )    0.104    0.749    0.371    0.199    0.793
 Regularly 2572 (25.5) 53 (18.9)   25 (17.2) 17 (18.7)   35 (18.9) 8 (15.4)   17 (15.2) 24 (19.2)   5 (19.2) 38 (18.5)  
 Occasionally 520 (4.8) 12 (4.3)   5 (3.4) 3 (3.3)   8 (4.3) 0   5 (4.4) 3 (2.4)   1 (3.89 7 (3.4)  
 Former smoker 4635 (43.0) 145 (51.7)   80 (55.2) 44 (48.4)   94 (51.4) 31 (59.6)   66 (58.9) 60 (48.0)   11 (42.3) 107 (52.2)  
 Never smoker 3046 (28.3) 70 (25.0)   35 (24.1) 27 (29.7)   48 (25.9) 13 (25.0)   24 (21.4) 38 (30.4)   9 (34.6) 53 (25.9)  
Smoking female (%)    0.652    0.592    0.972    0.009    0.694
 Regularly 4976 (29.8) 71 (23.4)   36 (22.6) 25 (24.3)   49 (22.8) 11 (23.9)   26 (20.2) 35 (26.1)   12 (26.7) 47 (22.1)  
 Occasionally 722 (4.3) 8 (2.6)   3 (1.9) 4 (3.9)   7 (3.2) 1 (2.2)   2 (1.6) 6 (4.5)   1 (2.2) 7 (3.3)  
 Former smoke 4637 (27.7) 87 (28.6)   41 (25.7) 30 (29.1)   57 (26.5) 13 (28.3)   27 (20.9) 43 (32.1)   9 (20.0) 59 (27.7)  
 Never smoker 7386 (44.2) 138 (45.4)   79 (49.7) 44 (42.7)   102 (47.4) 21 (45.7)   74 (57.4) 50 (37.3)   23 (51.1) 100 (46.9)  
Level of education male (%)    0.912    0.727    0.760    0.250    0.451
 Not completed 85 (0.8) 2 (0.7)   1 (0.7) 0   1 (0.5) 0   1 (0.9) 0   0 1 (0.5)  
 6-8 years 4852 (45.1) 137 (48.9)   76 (52.4) 41 (45.1)   93 (50.3) 25 (48.1)   57 (50.9) 61 (48.8)   13 (50.0) 102 (49.8)  
 9-10 years 2113 (19.6) 55 (19.6)   28 (19.3) 21 (23.1)   35 (18.9) 14 (26.9)   24 (21.4) 25 (20.0)   4 (15.4) 44 (21.5)  
 10-12 years 1279 (11.9) 29 (10.4)   16 (11.0) 10 (11.0)   21 (11.3) 4 (7.7)   7 (6.3) 18 (14.4)   6 (23.1) 20 (9.8)  
 1 year university 998 (9.3) 19 (6.7)   9 (6.2) 5 (5.5)   12 (6.5) 2 (3.8)   9 (8.0) 5 (4.0)   1 (3.8) 13 (6.3)  
 University degree 1424 (13.2) 38 (13.6)   15 (10.3) 14 (15.4)   23 (12.4) 7 (13.5)   14 (12.5) 16 (12.8)   2 (7.7) 25 (12.2)  
Level of education female (%)    0.009    0.019    0.796    0.496    0.316
 Not completed 126 (0.8) 3 (1.0)   1 (0.6) 2 (1.9)   3 (1.4) 0   2 (1.6) 1 (0.7)   0 3 (1.4)  
 6-8 years 6419 (38.5) 150 (49.8)   88 (56.4) 48 (46.6)   111 (52.4) 22 (47.8)   73 (56.6) 61 (46.2)   25 (55.6) 105 (50.0)  
 9-10 years 5086 (30.5) 75 (24.9)   27 (17.3) 35 (34.0)   52 (24.5) 12 (26.1)   26 (20.2) 38 (28.8)   13 (28.9) 50 (23.8)  
 10-12 years 1161 (7.0) 22 (7.3)   15 (9.6) 3 (2.9)   13 (6.1) 5 (10.9)   9 (7.0) 9 (6.8)   0 18 (8.6)  
 1 year university 1399 (8.4) 26 (8.6)   13 (8.3) 9 (8.7)   18 (8.5) 3 (6.5)   9 (7.8) 13 (9.8)   5 (11.1) 18 (8.6)  
 University degree 2496 (15.0) 25 (8.3)   12 (7.7) 6 (5.8)   15 (7.0) 4 (8.7)   9 (7.0) 10 (7.5)   2 (4.4) 16 (7.5)  
Alcohol (g/day)                
 Male 15.5 15.7 0.868 17.4 14.3 0.070 16.2 15.0 0.648   16.9 0.731 12.6 16.6 0.331
 Female 7.7 6.2 0.002 6.3 5.8 0.583 6.0 6.7 0.968 6.2 5.9 0.626 4.6 6.2 0.310
Height (cm)                
 Male 176.4 176.3 0.400 176.1 176.9 0.392 176.3 176.9 0.773 176.8 176.0 0.329 176.4 176.3 0.817
 Female 163.6 163.3 0.220 162.8 163.6 0.179 163.4 162.6 0.394 162.2 164.2 0.006 163.1 163.3 0.620
Weight (kg)                
 Male 81.7 83.8 0.014 83.9 82.9 0.953 83.1 84.5 0.457 84.6 82.8 0.250 86.2 82.8 0.433
 Female 68.0 70.0 0.008 70.9 68.3 0.112 70.4 71.0 0.881 69.0 71.5 0.154 68.9 70.7 0.484
BMI (kg/m2)                
 Male 26.2 26.9 <0.001 27.0 26.5 0.481 26.7 27.1 0.562 27.0 26.7 0.591 27.5 26.6 0.258
 Female 25.4 26.3 0.001 26.7 25.5 0.013 26.7 27.0 0.525 26.2 26.5 0.929 25.9 26.5 0.402
WHR (cm/cm)                
 Male 0.94 0.95 0.021 0.95 0.94 0.027 0.95 0.95 0.676 0.95 0.95 0.482 0.94 0.95 0.889
 Female 0.80 0.80 0.490 0.80 0.80 0.779 0.79 0.81 0.098 0.80 0.79 0.338 0.79 0.80 0.779
Waist (cm)                
 Male 94.0 96.3 <0.001 96.6 94.9 0.424 95.6 96.8 0.575 96.9 95.4 0.427 96.6 95.5 0.586
 Female 77.9 80.1 0.001 80.9 78.8 0.215 79.9 81.9 0.299 79.9 80.7 0.839 79.0 80.6 0.494
Hip (cm)                
 Male 99.4 101.2 <0.001 101.0 101.0 0.602 100.8 101.6 0.687 101.7 100.7 0.391 102.2 100.8 0.554
 Female 97.8 100.2 <0.001 101.2 98.8 0.091 100.4 101.0 0.872 99.5 101.4 0.287 99.6 100.9 0.380