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Table 4 Association between the percentage of surface receptors and cytotoxic granules positive NK cells and the clinicopathological features of gastric cancer

From: Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer

Gastric cancer

 

NO. of patients

NKG2D

NKp30

NKp46

Perforin

KIR3DL1

  

%

P

%

P

%

P

%

P

%

P

Histological grade

 

Well/Moderately

12

89.0 ± 3.0

< 0.01 T

45.1 ± 24.4

< 0.05 U

56.3 ± 28.7

ns U

88.5 ± 7.6

< 0.05 U

15.3 ± 5.9

ns U

Poorly

19

86.2 ± 2.5

 

31.2 ± 17.7

 

46.2 ± 30.1

 

76.5 ± 17.4

 

20.5 ± 14.3

 

Depth of invasion *

           

Tis/T1/T2/T3

10

87.8 ± 3.2

ns T

48.0 ± 24.3

< 0.05 T

54.2 ± 29.1

ns U

85.5 ± 10.0

ns U

21.4 ± 12.7

ns U

T4

21

87.0 ± 2.9

 

31.1 ± 17.8

 

48.1 ± 29.1

 

79.1 ± 17.3

 

17.2 ± 11.6

 

Lymph node metastasis

           

Absent

11

89.3 ± 2.8

< 0.01 T

48.2 ± 22.7

< 0.05 T

57.6 ± 29.3

ns U

88.5 ± 8.1

< 0.05 U

15.1 ± 5.7

ns U

Present

20

86.1 ± 2.5

 

30.1 ± 17.9

 

46.0 ± 29.5

 

77.1 ± 17.1

 

20.4 ± 14.0

 

Blood vessel invasion

           

Absent

17

88.3 ± 3.0

< 0.05 T

38.0 ± 23.8

ns T

49.0 ± 29.6

ns U

84.5 ± 12.0

ns U

18.3 ± 10.8

ns U

Present

14

85.9 ± 2.5

 

34.8 ± 18.4

 

51.4 ± 30.5

 

77.1 ± 18.5

 

18.8 ± 13.6

 
  1. *According to 2010 American Joint Committee on Cancer (AJCC), Tis, T1, T2, or T3 gastric cancer invades inside of gastric serosa; T4 gastric cancer invades outside of gastric serosa or adjacent organs. U represented Mann–Whitney U-tests and T represented independent t-tests. Data were expressed as means ± standard deviations (Mean ± SD).