Skip to main content

Table 5 Patients with stable disease (RECIST) for at least 4 cycles of treatment with dinaciclib

From: A first-in-human, phase 1, dose-escalation study of dinaciclib, a novel cyclin-dependent kinase inhibitor, administered weekly in subjects with advanced malignancies

Subject number

Diagnosis

Dinaciclib dose level (mg/m2)

Number of prior treatment regimens

Response by RECIST

Number of cycles

2902

NSCLC

0.66

16

SD

6

2910

Pseudomyxoma peritonei

2.59

3

SD

9

2913

Prostate cancer

3.63

2

SD

4

2920

Melanoma

3.63

3

SD

10

2926

Sarcoma

7.11

2

SD

12

2928

Gastrointestinal stromal tumor

7.11

2

SD

10

2931

Esophageal carcinoma

7.11

3

SD

11

2932

Adenoid cyst carcinoma

7.11

0

SD

5

2937

Adenoid cyst carcinoma

14.0

3

SD

8

2945

NSCLC

12.0

4

SD

4