Table 2 Administered dinaciclib dose levels and DLTs
Dose level (mg/m2) | Number of subjects | Subjects with DLT in cycle 1 | DLT |
|---|---|---|---|
0.33 | 1 | 0 | None |
0.66 | 1 | 0 | None |
1.32 | 1 | 0 | None |
1.85 | 4 | 0 | None |
2.59 | 4 | 0 | None |
3.63 | 8 | 1 | Hypokalemia, hypocalcemia, hypophosphatemia |
5.08 | 3 | 0 | None |
7.11 | 7 | 1 | Deep vein thrombosis |
10 | 3 | 0 | None |
12 | 11 | 1 | Septic shock |
14 | 5 | 2 | Orthostatic hypotension (1), elevated uric acid (1) |