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Table 2 Uni- and multivariate statistical analyses of the 12 potential screening markers selected on the basis of a 0.01% discrimination

From: Detection of serological biomarkers by proximity extension assay for detection of colorectal neoplasias in symptomatic individuals

Univariate analysis Multivariate analysis
TNMI-IV (N = 70 versus 210) Adenoma (N = 70 versus 140) TNMI-IVa(N = 70 versus 210) TNMI-IIb(N = 36 versus 108)
  Odds ratio (95% CI) P Odds ratio (95% CI) P Odds ratio (95% CI) *P Odds ratio (95% CI) P
CEA 2.2 (1.7-2.9) <0.001 1.2 (0.9-1.7) 0.2600 1.8 (1.3-2.4) 0.0003 2.0 (1.3-3.0) 0.0007
TFRC 2.8 (1.9-4.2) <0.001 1.0 (0.7-1.5) 0.9600 2.7 (1.5-4.8) 0.0007 2.1 (1.1-4.1) 0.0303
CA242 2.2 (1.7-3.0) <0.001 1.0 (0.7-1.3) 0.7700 1.6 (1.1-2.3) 0.0090 1.8 (1.1-3.0) 0.0311
OPN/ SPP1 13.4 (4.6-39.0) <0.001 1.7 (0.7-4.2) 0.2200 5.5 (1.3-23.1) 0.0200   
MIF 3.0 (1.8-5.1) <0.001 1.6 (1.0-2.5) 0.0400 2.6 (1.3-5.1) 0.0068   
NSE 2.0 (1.4-2.8) 0,0001 1.5 (1.1-2.2) 0.0240   0.6000   
CA19-9 1.5 (1.2-1.8) <0.001 1.1 (0.9-1.3) 0.4500   0.5900   
DcR3 1.7 (1.3-2.7) 0.0005 1.3 (1.0-1.8) 0.1100   0.6500   
IL8 2.4 (1.7-3.5) <0.001 1.2 (0.9-1.7) 0.2700   0.1500   
S100A8 4.9 (2.3-10.4) <0.001 1.4 (0.7-2.7) 0.3300   0.8600   
TIMP1 2.4 (1.6-3.5) <0.001 1.3 (0.9-1.9) 0.1300   0.1700   
TFF3 2.2 (1.5-3.1) <0.001 1.0 (0.7-1.3) 0.8100   0.3500   
  1. *P-value to include in final model. a Including all CRC stages (TNMI-VI) in a conditional logistic regression model; b Including only the early CRC stages (TNMI-II) in a conditional logistic regression model.
  2. Univariate analyses of the markers as discriminators of TNM stage I-IV demonstrate that all markers can discriminate CRC (n = 70) from the three control groups (n = 210). When including these markers in a multivariate analysis we find that five markers are still discriminators of CRC (n = 70). Including only CRC TNM I-II patients in the multivariate analysis we find that three markers are continuously discriminators of CRC. Univariate analyses of the markers as discriminators of adenomatous disease demonstrate that only one marker (NSE) is discriminator of adenoma (n = 70) and the two control groups, patients with other diseases and healthy individuals (n = 140).