Table 2 Uni- and multivariate statistical analyses of the 12 potential screening markers selected on the basis of a 0.01% discrimination

CEA

2.2 (1.7-2.9)

<0.001

1.2 (0.9-1.7)

0.2600

1.8 (1.3-2.4)

0.0003

2.0 (1.3-3.0)

0.0007

TFRC

2.8 (1.9-4.2)

<0.001

1.0 (0.7-1.5)

0.9600

2.7 (1.5-4.8)

0.0007

2.1 (1.1-4.1)

0.0303

CA242

2.2 (1.7-3.0)

<0.001

1.0 (0.7-1.3)

0.7700

1.6 (1.1-2.3)

0.0090

1.8 (1.1-3.0)

0.0311

OPN/ SPP1

13.4 (4.6-39.0)

<0.001

1.7 (0.7-4.2)

0.2200

5.5 (1.3-23.1)

0.0200

MIF

3.0 (1.8-5.1)

<0.001

1.6 (1.0-2.5)

0.0400

2.6 (1.3-5.1)

0.0068

NSE

2.0 (1.4-2.8)

0,0001

1.5 (1.1-2.2)

0.0240

0.6000

CA19-9

1.5 (1.2-1.8)

<0.001

1.1 (0.9-1.3)

0.4500

0.5900

DcR3

1.7 (1.3-2.7)

0.0005

1.3 (1.0-1.8)

0.1100

0.6500

IL8

2.4 (1.7-3.5)

<0.001

1.2 (0.9-1.7)

0.2700

0.1500

S100A8

4.9 (2.3-10.4)

<0.001

1.4 (0.7-2.7)

0.3300

0.8600

TIMP1

2.4 (1.6-3.5)

<0.001

1.3 (0.9-1.9)

0.1300

0.1700

TFF3

2.2 (1.5-3.1)

<0.001

1.0 (0.7-1.3)

0.8100

0.3500